H2020Индивидуална стипендия2017–2019

ARTFUL · Structure-activity relationships of an emerging family of fungal lytic polysaccharide monooxygenases

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-04-01 → 2019-03-31
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Ензимите на нишковидните гъби се анализират, за да се разбере как разграждат биомаса като дървесина и слама. Това помага за по-ефективното производство на горива и химикали, които да заменят нефтените продукти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Structure-activity relationships of an emerging family of fungal lytic polysaccharide monooxygenases

Sustainable production of fuels and chemicals from biomass (e.g. wood, straw…) is essential considering the societal and political demands for alternatives to petrochemical commodities. The main steps to obtain fuel from biomass include degrading biomass into simple molecules, and this achieved by enzymatic degradation. This step is however one of the major bottlenecks to achieve economically viable processes. Indeed, the very complex structure and heterogeneous composition of wood and other plants makes it difficult to degrade by available enzyme cocktails. In nature, filamentous fungi are among the most effective degraders of lignocellulosic biomass highlighting their potential as a source of novel and highly efficient carbohydrate-active enzymes. In this context, the Artful project main objective was to identify new enzymes with high potential of unlocking the conversion of biomass.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

During the past century, fossil-based hydrocarbons have been the main source of energy and chemicals, but in addition to be an unsustainable resource, they have led to important environmental concerns such as rising CO2 emissions. The great challenge for our societies is to develop alternative approaches for the sustainable production of energy and materials; the bioconversion of lignocellulosic biomass is one of them. Nevertheless, the physical and chemical recalcitrance of the biomass is the main obstacle to its cost-effective conversion as huge amounts of degrading enzymes are still required. Therefore, a significant improvement in enzymatic degradation is necessary, which involves enlarging the catalytic toolbox. By doing a large scale screening of the secretomes of a substantial fungal collection, the host organisation has shed light on the first member of a new family of lytic polysaccharide mono-oxygenases (LPMOs). LPMOs have been shown to boost the efficiency of cellulases industrial cocktails, thereby greatly reducing the financial and environmental penalties associated with the use of recalcitrant polysaccharides as a feedstock and, moreover, placing LPMOs at the center of considerable research interest. The objective of the ARTFUL project is the functional and structural characterization of the representative members of the new fungal LPMO family. The 6 years’ experience of the French fellow in the glycobiology field (biochemistry, enzymology, structural biology) combined with the expertise of Aix-Marseille University (France) in fungal omics form a solid basis that will be reinforce by the collaborations of experts. The quality of the hosting arrangements will maximise the training opportunities of the fellow and is suited for the two way transfer of knowledge. Acquired generated knowledge will provide a robust functional context to bioinformatic-based predictive biology as well as new enzymatic tools for subsequent industrial applications.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE D'AIX MARSEILLE · MarseilleКоординаторФранция