H2020Индивидуална стипендия2017–2019

DualFun · Dual Function Polymer Materials for Blood Contacting Applications

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-09-18 → 2019-09-17
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-CAR

Линиите свързват координатора с партньорите.

Накратко на български

Полимерни материали за медицински устройства се модифицират с мед, селен и аргатробан, за да се предотврати съсирването на кръвта и развитието на бактерии. Това помага за подобряване на безопасността на устройствата, които влизат в контакт с кръвта на пациентите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Dual Function Polymer Materials for Blood Contacting Applications

Biomedical devices are a vital option of lifesaving therapy to thousands of patients every day. Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Infection is another significant problem, with 1.7 million Healthcare Associated Infections that result in 99,000 deaths per year in the United States alone. Therefore, the aim of the project was to produce polymer materials with dual function: thromboresistant and antimicrobial. Cu and Se catalyst species were attached to polyvinyl chloride (PVC) and polyurethane (PU) for nitric oxide (NO) generation by decomposition of endogenous S-nitrosothiols (RSNOs) as NO prevents bacterial film formation, to inhibit platelet adhesion/activation. Argatroban (AG), a direct thrombin inhibitor, was chemically immobilized on the surface of polymers in order to inhibit any surface-produced thrombin. Cu/AG- and Se/AG-modified PVC and PU were characterized by physico-chemical methods. Cu/AG- and Se/AG-modified polymers showed NO generation ability in PBS and in human plasma. Cu/AG- and Se/AG-modified PU and PVC effectively inhibited thrombin activityin buffer system and in platelet poor plasma or platelet rich plasma, thus preventing the platelet activation and aggregation. Another important achievement is that modified polymers showed antibacterial effect. The project results will help to open wide opportunities for the improvement of the existing blood-contacting devices and design of new ones. The understanding of NO generation mechanism and argatroban activity may lead to the construction of the better quality blood compatible surfaces with more controllable properties. The applications for these materials range from the medical device technologies to the drug delivery systems in cardiovascular stenting, creation of biosensors for diagnostics and a smart textile design. The continuation of work can result in development of thromboresistant coatings on different polymers. Collaborative work with Teer Coatings resulted in development of smooth metal/mixed metal coatings on synthetic polymers. These coatings are the highest quality reagent-fee coatings for polymers which is “green way” alternative technology to produce such coatings with significant reduction in waste generation. All obtained Cu-coated polymers were able to generate nitric oxide. The project helped Dr Azizova to broaden her knowledge in the area of the surface chemistry of the implanted devices, antimicrobial activity, hemocompatiblity, thromboresistance, blood clotting, cell-biomaterial interactions. The University of Brighton provided Dr Azizova with opportunities to supervision/co-supervision of 5 student projects in pharmacy, biomedical science and biomaterials. The training obtained during MSCA fellowship has supported her professional development, strengthens her knowledge in project management, has helped her to widen scientific connections and network with researchers across the world.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Device-related thrombosis is associated with activation of blood clotting and platelets adhesion and activation. Infection of the implanted devices occurred as a result of bacteria adhesion to the biomaterial surface. A genuinely biocompatible polymer for blood-contacting devices should have both antithrombotic and antibacterial functionalities as both types of complication lead to an increase in morbidity, extended hospital stay and mortality.In order to prevent device-induced thrombosis and infection novel dual function polymer materials - thromboresistant and antimicrobial, will be produced. A novel and original approach that involves construction of multifunctional coatings, which combine formulation of the NO-generating surface with the ability to prevent bacterial adhesion, capacity to inhibit platelet adhesion and the use of surface bound argatroban drug to inhibit any surface-produced thrombin, will be applied. The polymer matrices chosen for the design of dual function materials are the most commonly used synthetic polymers polyurethane (PU) and polyvinylchloride (PVC) and the biopolymer collagen. This aim will be achieved by: i) chemical attachment of the organoselenium or copper nanoparticle catalysts to the polymer surface in order to continuously generate NO by decomposition of endogenous S-nitrosothiols; ii) immobilisation of the direct thrombin inhibitor argatroban to inhibit any thrombin in the surrounding environment. Catecholamines, polydopamine and poly(norepinephrine) will be used as the surface modification reagents, as they form very stable thin films strongly attached to the polymer surface. Owing to the chemical bonding of the ligand to the polymer surface it is expected that these materials will have long storage life and exploitation period and therefore retain their ability to generate NO from the inexhaustible endogenous NO donors.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF BRIGHTON · BrightonКоординаторОбединеното кралство