H2020Индивидуална стипендия2017–2019

SINMOF · Synthesis of Spirooxindoles and INdoles pharmaceuticals using Metal-Organic Frameworks

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-06-01 → 2019-05-31
Финансиране от ЕС: 160 800 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Метал-органичните рамки (MOF) се изследват като твърди катализатори за синтез на лекарства, например производни на индола. Това помага за намаляване на металните остатъци в крайните продукти, което е важно за безопасността на фармацевтичните препарати.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Synthesis of Spirooxindoles and INdoles pharmaceuticals using Metal-Organic Frameworks

This project is expected to establish a two-way knowledge transfer between the host and the applicant in the synthesis of bio-active indole derivatives using the last synthetic strategies of the partner organisation and new high performance hybrid solid catalysts design at the host institution. SINMOF is a pionering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in porous hybrid host materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts. Since metal residues are totally unallowed in pharmaceuticals (downstream processing imposes ≤20 ppm of Platinum-Group Metals or < 300 ppm of other metals). The strategies for selective C-H activation using homogeneous catalysts at the partner organisation will be translated, for the first time, to solid hybrid catalysts like MOFs. So far, the performance of state-of-the art MOFs as catalyst has been mainly tested in single acid-base or redox steps, with the host institution as one of the pioneers in the field. SINMOF project will provide novel MOFs that simultaneously host several types active sites, either as part of the lattice, or appended (e.g. covalent linkages). These can be simultaneously active for consecutive steps in a complex multi-step process due to well-positioned active sites in the solid MOF matrix.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

SINMOF is a pioneering and structured effort to comprehensively address the introduction of different immobilised isolated catalytic active sites in solid hybrid materials to overcome the metal losses occurring with state-of-the-art homogeneous catalysts employed in the pharmaceutical industry. The convenient use of hybrid metal-organic framework materials (MOFs) respect to traditional state-of-the-art porous solid materials is due to (a) self-deactivation-resistant design of the active sites by (b) ultrastable catalytic site isolation. In the SINMOF project we will (1) design novel multifunctional MOFs as next generation catalysts for the synthesis of pharmaceutically active compounds in an economically and environmentally beneficial way; (2) apply MOF hybrid solids as heterogeneous catalysts to avoid the use of homogeneous metal catalysts in novel synthetic strategies of pharmaceuticals with the indole core and finally (3) derive structure-activity and selectivity relationships at the smallest possible length scales and with the highest possible sensitivities employing fluorescence microscopy. Using a two-stage research methodology, SINMOF will finally provide the most active and stable MOF catalyst for the synthesis of the indole-based neurotransmitter Sumatriptan and the anticancerigen spirooxindole SAR405838. The combined expertise of the fellow and host ensures the best chance for successfully completing the SINMOF objectives in a mutually beneficial manner. On one side, internal collaborations at the host institution will allow the access to state-of-the-art fluorescence microscopy methods, to get new insights into the molecular mechanisms underlying the novel catalytic systems. On the other side, a secondment at a world-leading research center in the homogeneous catalysis field will train the researcher in order to individuate the best molecular features for model homogeneous catalysts to be translated into selective heterogeneous MOF catalytic system.

Оригинален текст от CORDIS (на английски).

Участници

KATHOLIEKE UNIVERSITEIT LEUVEN · LeuvenКоординаторБелгия