H2020Индивидуална стипендия2017–2021

HIPPOCRATE · Hybrid Imaging of PET and PrOmpt gamma for preCision RAnge- and biological- guidance in proton ThErapy

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-06-01 → 2021-05-04
Финансиране от ЕС: 171 461 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Хибридното медицинско устройство за PET и гама-изобразяване помага за точното проследяване на лъча при протонна терапия срещу рак. Разработването на нов метод за изчисление на данните подобрява качеството на изображенията, което намалява страничните ефекти при лечението.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Hybrid Imaging of PET and PrOmpt gamma for preCision RAnge- and biological- guidance in proton ThErapy

HIPPOCRATE’s main objective was the design optimization of an innovative hybrid medical imaging device that combines Positron Emission Tomography (PET) and prompt gamma imaging in the scope of high-precision proton therapy range monitoring. The development of such device contributes to the primary European policy goal in the scope of Health which is the promotion of longer and healthier lives for its citizens through innovative and revolutionary imaging and therapeutic approaches for cancer with minimal side effects. The main problem being addressed in HIPPOCRATE is the necessity of the Compton sensitivity matrix, i.e. the probability that a gamma-ray undergoes Compton scattering between the scatterer and the absorber detector, as an indispensable set of values that corrects the Compton image reconstruction voxel by voxel and poses a requirement for conducting research on the design of a Compton and/or hybrid medical imaging device (‘γ-PET’). HIPPOCRATE’s foremost priority was therefore given to the crucial task of developing an innovative method to calculate the Compton sensitivity matrix in a precise and time efficient manner. The validation of the novel method is presented in the final report, along with the technological quality of the method which is also supported by the successful image reconstruction of laboratory data using the Compton sensitivity matrix as calculated from the presented method.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Proton therapy is rapidly being established in the EU as a promising external beam tumour therapy modality offering an increased tumour-dose conformity with better sparing of critical organs and healthy tissue compared to conventional photon therapy. However, full exploitation of its clinical potential is still hampered by non-negligible uncertainties during the treatment planning and delivery, posing the urgent demand of novel real-time techniques for in vivo verification of the proton beam range. To this aim, the objective of this project proposal HIPPOCRATE (Hybrid Imaging of PET and PrOmpt gamma for preCision RAnge- and biological- guidance in proton ThErapy) is to explore the optimal design and clinical potential of an innovative hybrid medical imaging approach that goes well beyond the state of the art, by combining real-time range verification from energetic prompt gammas with Positron-Emission-Tomography (PET) imaging of irradiation-induced or externally injected tracers, to promote biological- and dose- guidance for personalized, high-precision proton therapy. By improving the quality of the rapidly emerging proton therapy modality, this project will promote longer and healthier lives for cancer patients, with a high societal impact on the EU. Moreover, HIPPOCRATE can potentially go beyond the boundaries of medical imaging in proton therapy, by enabling high quality imaging of a whole new range of promising unconventional radionuclides for diagnostic nuclear medicine imaging, as well as opening the perspective of biological image guidance at the radiotherapy treatment site, independent of the primary radiation quality.

Оригинален текст от CORDIS (на английски).

Участници

LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN · PlaneggКоординаторГермания