H2020Индивидуална стипендия2018–2020

PhotoNanoBone · Photoresponsive Smart Nanocarriers for Tetherless Regeneration of Bone Tissue

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-01-02 → 2020-01-01
Финансиране от ЕС: 158 122 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

„Умни“ наноносители от метал-органични рамки се тестват за управление на процеси в клетки, за да се стимулира регенерацията на костна тъкан. Разработването на такива платформи помага за развитието на терапевтичната наномедицина и подобряването на възстановяването на тъканите.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Photoresponsive Smart Nanocarriers for Tetherless Regeneration of Bone Tissue

The main goal of this project was to design stimuli-responsive “smart” nanoplatforms for performing different actions inside living cells, both in 2D configuration (adherent cells) and 3D configuration (cell spheroids as a tissue-like model structure). Metal-organic framework (MOF)-based nanocomposites were selected as the key nanomaterial to developed the “functional and customized” nanoplatform. This selection was based on the particular features of MOFs, in particular zeolitic imidazolate framework-8 (ZIF-8), which make them ideal candidates for bioapplications. These properties are mainly minimal cytotoxicity, intrinsic biodegradability, ultra-large surface-to-volume ratios, tunable pore size, high drug loading capacity, tunable structure and chemical composition, and potential for pre-/post-synthetic modifications for incorporating additional functionalities. This approach would represent a major advance in the nanobiomedical field, and could be also extended to wider application areas such as therapeutic and regenerative nanomedicine, with the consequent expected positive impact on the society.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The research aim of PhotoNanoBone is to develop of a novel nanotechnological strategy based on stimuli-responsive nanocarriers together with a microfluidic platform for spatiotemporal control of cell reprogramming and differentiation of 3D cell cultures towards bone tissue engineering. The project entails three steps. (1) Synthesising stimuli-responsive nanocarriers by layer-by-layer assembly and loaded with cell reprogramming factors (cargo). Polymeric walls of nanocarriers will be further functionalized with magnetic and plasmonic nanoparticles. By applying magnetic fields, nanocarriers can be locally enrichment in 3D cell culture. Upon external light irradiation, plasmonic nanoparticles will be heated, leading to local opening of the polymeric walls and subsequent cargo release. (2) Set-up of a microfluidic platform for externally controlled intracellular magnetic targeting and light-triggered release of cargo. (3) Application of the developed technology in 3D cell cultures of fibroblasts (mouse model) for bone tissue engineering. I (the ER) will prepare, characterize and test the materials and application proposed, with the support of a multidisciplinary hub of specialists. The prime training aim of PhotoNanoBone is to provide me with a truly solid formation in biomaterials, which will support my future career endeavors, both in the academia or industry, to be an independent researcher, a founder of a start-up company or to become key player in the biomaterials sector. I will be hosted by the Centre for Research in Biological Chemistry and Molecular Materials (CiQUS) of the University of Santiago de Compostela, a cutting-edge multidisciplinary research center at the interface of chemistry, biomedicine and molecular materials. The training will be further strengthened by two secondments focused on the following topics: synthesis of plasmonic NP with lasers (Complutense University Madrid) and development of microfluidic platforms (Micronit Michrotecnologies).

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSIDAD DE SANTIAGO DE COMPOSTELA · Santiago De CompostelaКоординаторИспания