MOBER · Maternal Obesity and Epigenetic Reprogramming: from Gametogenesis to Early Embryonic Development
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2017-12-01 → 2019-11-30
- Финансиране от ЕС
- 195 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Майчиното затлъстяване и влиянието му върху яйцеклетките и ранното развитие на ембриона се проучват чрез опити с мишки. Това помага да се разбере как хранителните навици могат да пренесат епигенетични промени към следващите поколения.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Maternal Obesity and Epigenetic Reprogramming: from Gametogenesis to Early Embryonic Development
Food choice and eating habits have dramatically changed over the last fifty years. Nowadays our society faces not only a notorious excess of caloric intake, but also a decrease in physical activity. Consequently, the escalating global epidemic of overweight and obesity is taking over many parts of the world. Obesity leads to long-term health problems. Remarkably, the impact of obesity on reproduction is understudied. Reproductive function gains relevance because gametes transfer not only genetic material, but potential alterations in epigenetic marks might be propagated to subsequent generations. Thus, the present research proposal investigated how maternal obesity promotes epigenetic changes in the oocyte and early embryo development. The objectives were to understand: (i) the extent to which the oocyte is vulnerable to maternal obesity; (ii) if changes established in the oocyte are able to interfere with the early embryo development. Different mouse strains reflecting variable susceptibility to obesity were subjected to diet-induced obesity protocols, representative of our social dietary habits.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Obesity is a worldwide epidemic with major health consequences. One devastating consequence of obesity is ovarian failure and infertility in women. Obesity causes endocrine dysfunction that compromises particularly the female gamete, the oocyte. Importantly, maternal obesity also affects the offspring, predisposing children to obesity and type 2 diabetes. In the present proposal we will build on the unique expertise of the host lab and research experience of the postdoctoral fellow to address how maternal obesity promotes epigenetic changes in the oocyte and affects early embryonic development. The proposal will exploit the synergies between two laboratories in a multidisciplinary research setting. The candidate has a background in reproductive medicine and endocrinology, with 5 years of postdoctoral experience over which the candidate has been producing a relevant body of preliminary data on obesity and ovarian failure. The partner laboratory in Poland will contribute know-how and animal models for the study of obesity, as well as support from the local team. The host laboratory will provide methods and access to state-of-the-art facilities for epigenetic analysis. Our results, will enable us to clearly understand: (i) the extent to which the oocyte is vulnerable to maternal obesity; (ii) if epigenetic changes established in the oocyte interfere with early embryonic development. We will analyse the oocyte and early embryo epigenome and transcriptome of mouse strains with different susceptibilities to obesity and diet-induced obesity protocols representative of our social dietary habits. We will critically assess the potential health consequences of maternal obesity for the offspring. Ultimately, the knowledge generated through this proposal will lead to the public sector being better informed and new political and pharmacological strategies can be conceived for the improvement of female fertility and prevention of disease in offspring.
Оригинален текст от CORDIS (на английски).
Участници
- THE BABRAHAM INSTITUTE · CambridgeКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз