JTIM · Biodegradable Water-Soluble Cylindrical Block Copolymer Micelles and their Applications in Nanomedicine
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-03-15 → 2020-03-14
- Финансиране от ЕС
- 195 455 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Биоразградими полимерни структури във формата на цилиндрични нанофибри се разработват за транспортиране на лекарства в организма. Тези преносители помагат за създаването на по-точни и контролирани методи за доставка на медикаменти в наномедицината.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Biodegradable Water-Soluble Cylindrical Block Copolymer Micelles and their Applications in Nanomedicine
Block copolymer (BCP) self-assembly in solution has attracted considerable attention for many decades because it can yield ordered nanoscopic core-shell structures (micelles) with a wide range of morphologies, including spheres, cylinders, lamellae, and vesicles. These aggregates offer potential applications in many fields and cylinders are among the most promising for uses in nanomedicine (e.g. as drug delivery vehicles (DDVs)). Living CDSA offers the opportunity to create highly uniform populations of precisely designed drug delivery vehicles (DDVs) as it is possible to prepare monodisperse cylinder samples (also called nanofibers) of controlled length and to access block comicelles with tailored segmented structures. A series of monodisperse nanofibers have been fabricated and studied systematically with length optimisation for different targeted applications. Exciting work including the development of various biodegradable block copolymer systems and the fabrication of novel water-compatible nanofiber assemblies for drug delivery have been accomplished by the MSCA researcher Dr. Jia Tian. Additionally, 2 articles had been submitted to top journals and now one is under review, and 1 article is under preparation. Dr. Jia Tian also presented those work at international conferences and departmental symposia, and highlighted to the general public at University Open Days and a European Researchers’ night. Several other papers have also been drafted from publication and should be submitted in due course.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Block copolymer (BCP) self-assembly in solution has attracted considerable attention for many decades because it can yield ordered nanoscopic core-shell structures (micelles) with a wide range of morphologies. These aggregates offer potential applications in many fields, and cylinders are among the most promising for uses in nanomedicine (e.g. as drug delivery vehicles). In this proposal, state-of-the-art strategies to access well-defined micelles with tailored structures will be applied to the preparation of biodegradable monodisperse cylindrical micelles and block comicelles in water. Once formed, the micelles and their hierarchical assemblies will be characterized in detail and explored in potential nanomedical applications. To achieve these objectives Dr. Jia Tian, an exceptionally talented young scientist from China who performed his Ph.D. in a top supramolecular chemistry group in China (Zhan-Ting Li, Fudan University), will work in the internationally leading polymer and materials research group of Prof. Ian Manners (Bristol, UK) where he will learn polymer synthesis and state-of-the-art self-assembly techniques and will obtain a broad background in polymer and BCP synthesis, self-assembly, and polymer materials science. Armed with the new knowledge and experience gained, following the fellowship Dr. Tian aims to obtain an academic position in China where soft materials such as biodegradable BCPs and their applications in nanomedicine will play a key role.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY OF BRISTOL · BRISTOLКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз