H2020Индивидуална стипендия2017–2019

ADOC · Characterization and monitoring of vigilance fluctuation in disorders of consciousness

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-08-01 → 2019-11-10
Финансиране от ЕС: 160 800 €
Участници: 1
Схема: MSCA-IF

Линиите свързват координатора с партньорите.

Накратко на български

Колебанията в нивото на бдителност при пациенти с тежки мозъчни увреждания се проследяват чрез електроенцефалография и реакции на очите. Това помага за намаляване на грешните диагнози, които влияят върху лечението на болката и етичните решения за живота.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Characterization and monitoring of vigilance fluctuation in disorders of consciousness

The clinical diagnosis of consciousness in patients with severe brain injury is mainly based on bedside observation of the patient's responses to the environment using standardized neurobehavioral scales. However, they are not all reliable and studies have revealed that about 40% of the patients are clinically misdiagnosed as being unconscious. In addition, as the probability to detect voluntary responses depends on the patient's level of vigilance at the time of assessment, multiple assessments are needed to detect signs of consciousness and, consequently, to avoid misdiagnoses. Misdiagnoses can lead to critical ethical consequences, especially in terms of end-of-life decision-making and pain treatment. In this project, we aimed at better characterize vigilance fluctuation (as defined by a change in behavioral responsiveness during the day) in patients with severe brain injury using neurophysiological parameters (i.e., eye responses, electroencephalography, actigraphy).

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This prospective exploratory study will aim at characterizing vigilance fluctuation in patients with disorders of consciousness (as defined by a change in diurnal behavioral response over time) using neurophysiological parameters. We based this project on the assumption that changes at the Coma Recovery Scale-Revised scores (i.e., behavioral responsiveness) will be associated with a change in ocular measures and EEG complexity, suggesting that some of these parameters could be used for monitoring vigilance in this population. We expect that this fluctuation will be particularly marked in patients with a minimally conscious state as compared with patients in an unresponsive wakefulness syndrome who will display a more stable pattern of response over the two days. This project aims to better understand the course of vigilance fluctuation in DOC and to develop an objective tool based on biomarkers that could be used at bedside to determine the best periods to assess and treat these patients.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE DE LIEGE · LIEGEКоординаторБелгия