H2020Индивидуална стипендия2017–2019

EXPOZOL · Exposure of aquatic ecosystems to antifungal azoles : assessment of occurence and fate in sediment, water and aquatic organisms

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-09-15 → 2019-10-26
Финансиране от ЕС: 175 420 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Противогъбичните лекарства от групата на азолите се проследяват във водите, улуците и организмите, като например при рибите. Те могат да нарушат хормоните и развитието на водните видове, затова е важно да се оцени рискът за околната среда.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Exposure of aquatic ecosystems to antifungal azoles : assessment of occurence and fate in sediment, water and aquatic organisms

Antifungal azoles englobe both the triazole and imidazoles chemical classes. They are widely used as agricultural fungicides or pharmaceuticals to treat mycoses, parasitic infections and cancer in humans. Initially designed to inhibit CYP51 enzymes, responsible for the biosynthesis of the ergosterol in fungi, they also disrupt a broad range of other CYPs involved in steroidogenesis (e.g. CYP19) and xenobiotic detoxification (e.g. CYP1A) in mammals and aquatic species. Thus, they have the capacity to act as endocrine disruptors and to affect survival, development, growth, reproduction and behaviour of non-target organisms. Although a few of these compounds are routinely investigated and detected, an accurate exposure assessment of most of them was still lacking to evaluate the associated environmental risk. The project aimed to fill the gap of knowledge regarding the occurrence, the fate and effect(s) of antifungal azoles in aquatic ecosystems in order to improve environmental risk assessment. First, we studied the distribution of antifungal azoles in various environmental matrices and biota using availability HRMS raw data. Second, we investigated the toxicokinetic (TK) of azoles (i.e. prochloraz, propiconazole, tebuconazole) and their metabolites and the associated effect(s) (TD) in invertebrates and fish cells.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This project aims to provide a comprehensive characterization of the exposure of aquatic organisms to antifungal azoles (AFAs), an emerging pollutant family of particular concern as regard to their endocrine disrupting effects, in the frame of their environmental risk. To this end, this project will address different scientific and technical challenges as regards distribution, bioavailability, toxicokinetic, and (bio)transformation products ((bio)TPs) of AFAs. For this purpose , a multi-disciplinary approach, based on bio-monitoring, passive sampling, effect-driven approach, cutting-edge high resolution mass spectrometry-analyses and laboratory experiments will be implemented. This comprehensive approach will allow (1) to characterize the distribution of AFAs in aquatic systems between sediment, surface water and biota; (2) to identify bioTPs (and biotransformation pathways) of AFAs at different trophic levels but also TPs from other relevant processes (e.g. hydrolysis). This project is original and innovative since it aims to gain knowledge on exposure and identity of (bio)TPs and thus addresses a crucial issue in the assessment of environmental contamination by emerging pollutants and their associated risk. In addition, it proposes to better link exposure and hazard by studying the bioavailability of potentially hazardous chemicals directly in the organisms. It also compare passive sampling vs biomonitoring at different trophic level for a more relevant exposure monitoring of emerging pollutants such as AFAs. This might also enhance human health risk assessment by providing tools for better evaluate exposure, and so risk, associated to consumption of contaminated food (i.e. fish). Finally, if we focus in the present project on AFAs and their (bio)TPs, the approach proposed here could provide a conceptual framework for exposure assessment of other classes of emerging contaminants that would help to enhance actual environmental risk assessment for aquatic organisms.

Оригинален текст от CORDIS (на английски).

Участници

EIDGENOESSISCHE ANSTALT FUER WASSERVERSORGUNG ABWASSERREINIGUNG UND GEWAESSERSCHUTZ · DubendorfКоординаторШвейцария