H2020Индивидуална стипендия2018–2020

CALLIRHEO · Multi-scale computational hemodynamics in obese children and adolescents: enabling personalised prediction of cardiovascular disease

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-03-01 → 2020-02-29
Финансиране от ЕС: 183 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Кръвният поток в артериите на деца и юноши с затлъстяване се анализира чрез 3D компютърни симулации. Това помага за по-доброто разбиране на съдовите промени, предизвикани от теглото, и за предсказване на сърдечно-съдови заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Multi-scale computational hemodynamics in obese children and adolescents: enabling personalised prediction of cardiovascular disease

Childhood and adolescent obesity, primarily a dietary disease, has become a major challenge in recent decades. Obesity is known to accelerate the initiation of endothelial dysfunction, one of the key biological indicators of lesions of atherosclerosis that underlie most cardiovascular diseases. In line with recent European and worldwide policies on understanding childhood adiposity, the CALLIRHEO project aimed to develop an efficient multi-scale computational framework that would allow for the 3D blood flow analysis of young arteries. The project also aimed to perform patient-specific numerical simulations, correlated with medical data, for the investigation and assessment of flow-related disease markers. This research could have a significant impact for the society, in understanding obesity-induced vascular changes in children, and for the healthcare industry and medical science, in advancing novel methodologies. The scope and scientific objectives of the CALLIRHEO project were achieved within the timeframe of the project resulting in a considerable number of publications, public engagement activities, and application of a patent.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Childhood obesity is currently at epidemic rates, with serious risks for cardiovascular disease in adulthood and premature death. Obesity is known to accelerate the initiation of endothelial dysfunction and alter the hemodynamics in young arteries. In alignment with urgent EU and worldwide policies on understanding childhood adiposity, we propose to develop a novel and safe computational tool to study numerically, for the first time, the obesity-altered hemodynamics in children and adolescents. The project aims to transfer the non-invasive computational fluid dynamic technology to the paediatric practice and enable personalised prediction of cardiovascular disease and effective decision-making. Within a multi-scale modeling framework, the proposed study seeks to utilise high-fidelity state-of-the-art numerical methods and develop new ones, for the implementation and coupling of the 3D flow in anatomically realistic arterial geometries with macroscopic and microscopic information, ensuring high stability and accuracy of results. In conjunction with clinicians, the study will perform patient-specific numerical simulations, correlated with medical data, and help towards individualized treatment planning, with a significant impact on the quality of life of the young patient. This multidisciplinary perspective is fundamental in elucidating early vascular changes induced by obesity and predict cardiovascular disease risks, while protecting the young population.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF STRATHCLYDE · GlasgowКоординаторОбединеното кралство