H2020Индивидуална стипендия2018–2020

GlucoTear · Non-Invasive Fluorescence-based Tear Glucose Sensor Integrated to a Smartphone

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-03-01 → 2020-02-29
Финансиране от ЕС: 170 122 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Сензор с флуоресцентни въглеродни частици, свързан със смартфон, измерва нивата на глюкоза в сълзите. Това помага за следене на диабета без нуждата от болезнени убождания в пръстите за вземане на кръв.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Non-Invasive Fluorescence-based Tear Glucose Sensor Integrated to a Smartphone

"Diabetes is the most common endocrine metabolic disorder that is currently afflicting nearly half a billion people worldwide according to IDF diabetes atlas 2019. It is associated with elevated blood glucose levels and causes complications such as heart diseases, retina degeneration, kidney failure among others. Diabetes patients must therefore regularly monitor blood glucose to maintain glycemic balance as a regimen or prophylactic measure. Up to now, the glucose meters commonly used for this purpose involve painful finger pricking about 4-5 times a day to obtain blood samples. Since diabetes is a lifelong health compilation, the problems caused by continuous finger pricking cannot be overemphasized. The general implication is that it leads to patient non-compliance and hence poor diabetes management. The other alternative to this painful point-sample self-monitoring is the continuous glucose monitoring using implantable devices. However, the present generations of these devices require routine replacement and calibration by the finger pricking method. Additionally, they are expensive and therefore tightly regulated by insurance companies. A viable option for general public interest is non-invasive blood glucose self-monitoring which has remained a worldwide goal despite over 4 decades of innovation in this field. In the GlucoTear project, the objective is to develop fluorescence-based glucose sensor that is integrated to a Smartphone and utilizing fluorescent carbon particles capable of detecting glucose concentration in tear samples. This would avoid finger-pricking method and instead use tear samples that are obtained non-invasively. Overall objectives include: (i) to generate non-toxic fluorescent carbon nanoparticles using laser-based technologies, which are innovative ""green""approaches in the field of nanomaterial synthesis, (ii) to develop a non-invasive, reliable and portable tear glucose sensor based on the fluorescence signals to be detected by a smartphone camera, (iii) to correlate the results of the fluorescence-based tear glucose testing with that of the clinically approved blood glucose sensor in pursuit of a homecare/POC device. The project achieved most of its objectives and milestones for the period, with relatively minor deviations. Further clinical study for the validation of the developed tear glucose sensor is required."

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The prevalence of diabetes is continuously rising even in low-income economies. Therefore, blood glucose monitoring tools are in high social demand globally. Uninterrupted monitoring of blood glucose is a must in order to keep the fatal levels of glycated hemoglobin under control and to improve the quality of life for diabetic patients. However, glucose monitoring is compromised by the painful finger pricking about 4-5 times a day to obtain blood samples which leads to patient non-compliance and hence endangering their lifes.The main objective of NANOTEARS is the development of a non-invasive diabetes diagnostic tool by detecting in vitro ocular glucose that is ready to be integrated in a smartphone for point of care and homecare use. Compared to other body fluids, tears are more accessible than blood or interstitial fluid, more continuously obtainable, and less susceptible to dilution. So, it is a worthwhile alternative to finger pricking for repetitive monitoring. Additionally, the use of a cell phone enables systematically collection and management of glucose level records in electronic form in order to reduce medical errors and improve quality of care and promote evidence-based medicine. Our sensing strategy is based on the use of fluorescent spectroscopy. Taking into account, that glucose concentration in tear fluid is about 50-100 lower than the glucose in blood there is a need to enhace the emitted signal to meet the accuracy and tolerance as recommended in the ISO 15197:2013. To reach this goal, we will fabricate highly fluorescent nanocomposite consisting of functionalized carbon quantum dots embedded into mesoporous silica. The entire synthesis will be performed without the need to use residual chemical precursors and stabilizers allowing for “green synthesis”, owing to the use laser ablation in liquids. The use of femtosecond disruptive technology will enable to circumvent the limitations imposed by the low speeds at which nanoparticles are ablated.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITAT JAUME I DE CASTELLON · Castellon De La PlanaКоординаторИспания