H2020Индивидуална стипендия2018–2020

cTerF · Realizing a development platform for sustainable sun powered production of intermediates for chemical industry.

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-01-02 → 2020-01-01
Финансиране от ЕС: 177 599 €
Участници: 1
Схема: MSCA-IF-EF-SE

Линиите свързват координатора с партньорите.

Накратко на български

Генетично модифицирани цианобактерии се тестват като „клеточни фабрики“ за производство на химикали, например L-лактат за биопластмаси. Това помага за създаване на екологични технологии, които не изразходват захар или земеделски площи, необходими за хранителните нужди на хората.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Realizing a development platform for sustainable sun powered production of intermediates for chemical industry.

"Photanol's technology and patents rely on the genetic manipulation of photosynthetic bacteria, known as cyanobacteria, to become the standard source of renewable, bio-based, chemical commodities. Despite cyanobacteria being attractive platforms for chemical production, their widespread implementation in the global economy has been hindered by myriad factors ranging from insufficient chemical output to concerns about the impact these may have if accidently released into ecosystem. Ongoing efforts within, and beyond, the scope of cTerF are focused on screening and testing multiple cyanobacterial candidates to identify a robust candidate to balance industrially-relevant chemical output without a severe loss of cell fitness. Furthermore, biocontainment efforts are critical in order to allow safe large-scale growth and processing of the genetically manipulated cyanobacteria. The successful development of cyanobacteria as robust ""cell factories"" to cater to industries from cosmetics to pharmaceutics will be the first necessary step towards supplanting more traditional bio-based, less environmentally-friendly, technologies that rely on sugar-requiring bacteria and even photosynthetic-based platforms such as plants, which can compete with arable land that could otherwise be devoted to the food demands of an ever increasing human populace. The objective of cTerF was to conduct pilot studies to translate current and novel metabolic engineered pathways into a variety of cyanobacteria in search of a suitable candidate to develop as a ""cell factory"" for the production of chemical commodities such as L-lactate, a widely-used food additive and a feedstock for the production of PLA (poly lactic acid, a bioplastic). In addition to this objective, cTerF explored new avenues for bio-containment of genetically manipulated cyanobacteria that would simultaneously decrease the incidence of contamination by foreign microorganisms capable of metabolizing the target product."

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The objective is to develop a base cyanobacterial cell factory for terpene precursors that can be the development platform for commercial terpene production with cyanobacteria.Trends such as growth in world population, higher energy and food demand, depletion of raw materials and global warming make it necessary to implement breakthrough bio-based production technologies. A breakthrough is the use of genetically engineered cyanobacteria that turn CO2 directly and efficiently into predetermined products when exposed to light. This CO2-consuming process is based on circular economy principles and independent of first generation (food crop) feedstocks.A promising group of products for cyano-based production are terpenes and terpenoids. These compounds are of interest to chemical industry due to their potential of producing platform chemicals that are now obtained from fossil fuels. Terpenes have an advantage over other biobased commodities because they are drop-in chemicals that can be processed in much the same manner as crude oil.Despite potential uses in the medicine, food and fragrance sectors, the natural abundance of terpenes is too low for industrial production. Many approaches have been sought to engineer microbial strains capable of producing terpenoids in high yields. Up to now these do not result in increased production rates to the high levels needed. The project addresses this problem by producing a cyanobacterial strain capable of synthesizing high-levels of cell metabolite building blocks as an avenue towards the terpene production.The SME host, together with industrial partners, develops and markets cyano-based production technology. The fellow’s work will strengthen this and will give him the experience to establish a career in industrial R&D and entrepreneurship. A research and training program with ample industrial and academic interaction, supported by dissemination and communication actions, has been set up to realise this impact.

Оригинален текст от CORDIS (на английски).

Участници

PHOTANOL BV · AmsterdamКоординаторНидерландия