H2020Индивидуална стипендия2017–2019

GLUCOTANYCYTES · a role for hypothalamic barriers in the control of metabolism by peripheral glucose

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-12-01 → 2019-11-30
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Специални клетки в хипоталамуса, наречени таницити, се изследват като „пазачи“, които контролират достъпа на глюкозата и хормоните от кръвта до мозъка. Това помага за разбирането на механизмите при затлъстяването, диабета тип 2 и метаболитния синдром.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Glucotanycytes: a role for hypothalamic barriers in the control of metabolism by peripheral glucose

"The escalating epidemic of obesity, type-2 diabetes (T2D) and metabolic syndrome represents one of the most pressing and costly biomedical challenges confronting modern society. The impaired action of peripheral hormones like leptin, insulin and incretins on brain circuits controlling feeding and energy homeostasis (also known as ""central hormone resistance""), is increasingly recognized as playing a role in the pathophysiology of these disorders. Those hormones transmit information about the energy status of peripheral tissues, such as pancreas, liver, white and brown adipose tissue and gastrointestinal track. These hormones reach their central brain targets by crossing the blood-brain barrier at the level of microvessels or at circumventricular organs (CVOs) such as the median eminence, situated adjacent to the arcuate nucleus of the hypothalamus. Appetite, energy balance, glucose and lipid metabolism are all partially controlled by select neurons located in the arcuate nucleus of the hypothalamus (ARH). However, much remains to be uncovered concerning the physiological mechanisms that control the access of blood-borne metabolic factors such as glucose and peripheral hormones to ARH neuronal circuits. The laboratory where this project has been conducted (Development and Plasticity of the Neuroendocrine Brain, INSERM U1172, Lille, France) has raised the groundbreaking notion that tanycytes from the median eminence, a specific type of hypothalamic glial cells, act as ""gatekeepers"" that regulate the access of blood-borne signals to the hypothalamus, and in particular, their vesicular transport into the cerebrospinal fluid, from where they enter metabolic-hormone-sensitive regions. The overall objective of the GLUCOTANYCYTES project is to elucidate the function of hypothalamic tanycytic barriers in the control of energy homeostasis with respect to glucose metabolism and peripheral hormone access to the hypothalamus."

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The escalating epidemic of obesity, type-2 diabetes and metabolic syndrome represents one of the most pressing and costly biomedical challenges confronting modern society. The impaired action of peripheral hormones on brain circuits controlling feeding and energy homeostasis, also known as ""central hormone resistance"", is increasingly recognized as playing a role in the pathophysiology of these disorders. The host laboratory has raised the groundbreaking notion that tanycytes, a specific type of hypothalamic glial cells, act as ""gatekeepers"" that regulate the access of blood-borne signals to the hypothalamus, and in particular, their vesicular transport into the cerebrospinal fluid, from where they enters other metabolic-hormone-sensitive regions. The overall objective of this proposal is to further develop this highly original angle by using state-of-the-art approaches to i) gain new insights into the molecular mechanisms underlying structural changes in the tanycytic barrier in response to fluctuating concentrations of circulating glucose, and determine how these processes are altered in animal models with acquired type-2 diabetes, and ii) explore the possibility that tanycytes are involved in the shuttling of circulating glucose into the cerebrospinal fluid (CSF) and that the tanycytic expression of the NMDA receptor plays a role in this process. This research promises to shed new light on the molecular mechanisms used by the hypothalamus to integrate key peripheral signals and coordinate energy homeostasis. The results will pave the way for the development of new treatment strategies to overcome hormone resistance in human obesity and associated metabolic syndromes.""

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE DE LILLE · LilleКоординаторФранция