SELFIEv2.0 · Identifying the neuronal basis of self-concept in the human medial prefrontal and medial temporal brain regions
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-03-01 → 2023-02-28
- Финансиране от ЕС
- 265 059 €
- Участници
- 2
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Невронните механизми, чрез които мозъкът кодира представата ни за себе си, се анализират чрез запис на активността на отделни клетки. Разбирането на тези процеси помага за бъдещата диагностика и лечение на психични разстройства като депресията.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Identifying the neuronal basis of self-concept in the human medial prefrontal and medial temporal brain regions
Self-concept is one’s idea of who one is as a person. This complex mental construct allows us to make sense of the world and thrive as social individuals, but negative and rigid beliefs about oneself are related to reduced motivation and depression. Despite the importance of self-concept for mental health, how neurons in the human brain encode knowledge and beliefs about the self is unknown. The aim of this EU project funded by the Marie Skłodowska-Curie Action is to characterize the neurophysiological mechanisms of self-concept representation for the first time. We use the state-of-the-art methods of single-neuron recordings in human subjects implanted with depth electrodes for the diagnosis of epilepsy. The project is a collaboration between the Karolinska Institute in Sweden and the University of California, Los Angeles, USA. We have collected and analyzed data from more than thirty participants and identified unique patterns of brain activity related to the encoding and retrieval of self-relevant information. These key findings have important implications for the future diagnosis and treatment of psychiatric disorders characterized by an atypical sense of self, including depression. Apart from providing novel scientific insights, the project has established new international collaborations and allowed significant transfer of knowledge.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Humans have a remarkable ability to construct a complex conceptual representation of their own identity and personality. This self-concept plays a crucial role in everyday life; however, its neurobiological basis remains unknown. Here, we will use the state-of-the-art method of intracranial electroencephalography (iEEG) to characterize the neuronal representation of self-concept at the level of single-neurons in the medial prefrontal and medial temporal brain regions. IEEG will be recorded from awake human subjects, which is possible because a subset of neurosurgical patients requires placement of intracranial electrodes to identify the focus of epileptic seizures. We will conduct our studies during this monitoring time, with no added risk to the patients. Our data will provide unprecedented insights into the neuronal basis of the human self. Our findings will be of great interest to scientists in a broad range of disciplines, including neuroscience, psychology, artificial intelligence, neurology, psychiatry, as well as to the general public. The supervisors are world-leading experts in the neural self-representation (Prof. Ehrsson) and iEEG (Prof. Fried). Their laboratories conduct excellent research, as documented by multiple high-impact publications. The host institution (Karolinska Institute) and the partner institution (University of California, Los Angeles) are among the best universities in the world. Together, the fellowship provides an exceptional opportunity for the experienced researcher to become a leader in his field; he will learn the unique method of iEEG and he will collect the very first data on the neuronal basis of the conceptual self.
Оригинален текст от CORDIS (на английски).
Участници
- KAROLINSKA INSTITUTET · STOCKHOLMКоординаторШвеция
- THE REGENTS OF THE UNIVERSITY OF CALIFORNIA · OaklandСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз