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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2018–2022

IGNITE · Comparative genomics of non-model invertebrates

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2018-01-01 → 2022-06-30
Финансиране от ЕС
3 810 631 €
Участници
19
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Геномите на малко изследваните безгръбначни животни се анализират чрез нови софтуерни инструменти за стандартизация на данните. Това помага за разбирането на еволюцията, биоразнообразието и откриването на вещества, които могат да се използват за създаване на лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Comparative genomics of non-model invertebrates

Genomes provide records of the organism’s evolutionary history that can be exploited to understand key biological questions, such as the relationships among organisms, their key functional traits, and the evolution of biodiversity. Furthermore, genomes can help understanding normal versus aberrant development of animals (including humans), regeneration, and the origin of diseases. Also, genomes enable the study of pathways related to the production of biochemically active compounds that are potential drugs targets for human health benefit. Despite >95% of the Earth’s animal biodiversity being non-vertebrates, the current tally of sequenced genomes does not reflect this diversity and many traits and potential bioproducts of human benefit remain unknown. The first objective of IGNITE is increasing the availability of invertebrate genomes from as yet underrepresented lineages to establish resources to explore the likely vast potential encoded in genomes of spineless animals. The analysis of genome data involves several computationally intensive steps, such as genome assembly from raw data, gene prediction, comparative gene/genome and phylogenetic analyses. Limitations concerning the lack of international standards with respect to computational code and availability of analytic tools currently limit our capabilities to comprehensively analyse and understand the massive amount of information contained in invertebrate genomes. Consequently, IGNITE’s second objective is to develop novel tools to standardise genome data analyses, make it more computationally efficient, and to enable the continued rapid generation of high-quality genomes.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Invertebrates, i.e., animals without a backbone, represent 95% of animal diversity on earth but are a surprisingly underexplored reservoir of genetic resources. The content and architecture of their genomes remain poorly known or understood, but such knowledge is needed to fully appreciate their evolutionary, ecological and socio--economic importance, as well as to leverage the benefits they can provide to human well-being, for example as a source for novel drugs and biomimetic materials. Europe is home to significant world-leading expertise in invertebrate genomics but research and training efforts are as yet uncoordinated. IGNITE will bundle this European excellence to train a new generation of scientists skilled in all aspects of invertebrate genomics. We will considerably enhance animal genome knowledge by generating and analysing novel data from undersampled invertebrate lineages and developing innovative new tools for high-quality genome assembly and analysis. Well-trained genomicists are in increasing demand in universities, research institutions, as well as in software, biomedical, and pharmaceutical companies. Through their excellent interdisciplinary and intersectoral training spanning from biology and geobiology to bioinformatics and computer science, our graduates will be in a prime position to take up leadership roles in both academia and industry in order to drive the complex changes needed to advance sustainability of our knowledge-based society and economy.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз