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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2018–2022

LightDyNAmics · DNA as a training platform for photodynamic processes in soft materials

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2018-04-01 → 2022-10-31
Финансиране от ЕС
3 827 591 €
Участници
17
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между светлината и меките материали се изучава чрез ДНК, като се разработват нови методи за наблюдение на процесите в реално време. Това помага да се разбере как светлината може да повреди генетичния код, което води до рак или клетъчна смърт.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

DNA as a training platform for photodynamic processes in soft materials

Light and soft matter interaction is essential to our life and society, being the basis of fundamental biological processes and technological advances. In order to fully master such processes, we have to understand them from the atomic level to the material scale. This is a tremendous challenge and requires the integration of many techniques, from those already existing to those newly in development, incorporating both experimental and computational approaches. The objectives of LightDyNAmics were developing these methods (Work Package 1), using DNA as a training ground (Work Package 2), and applying the knowledge obtained to other multi-chromophoric assemblies, MCA (Work Package 3). The partners of LightDyNAmics (ten leading research institutions, three companies + 12 partner organisations in nine European countries) choose to focus mainly on a single system, to make the transfer of knowledge between the different partners easier, which is why DNA was selected as a training ground. The interaction between light and DNA has a fundamental biological relevance since it can damage genetic code and lead to cellular death and cancer. At the same time, the study of this flexible MCA allows most of the challenges ahead in this field to be tackled. In particular, our research activities aimed to: 1. Develop new time-resolved experimental spectroscopic techniques with both higher temporal resolution and increased sensitivity. 2. Develop new computational methods to allow the simulation of time-resolved spectra, and to describe the excited state dynamics in MCA from femtoseconds to milliseconds. 3. Apply these techniques to representative DNA systems, from nucleobases to quadruple helices, as well as sequences containing newly discovered epigenetic bases. 4. Develop new DNA ligands for diagnostic and therapeutic use. At the heart of these developments were our 15 early stage researchers (ESRs) who were trained in these multi-disciplinary approaches, cross-developing experimental and computational skills, to become the next generation of scientists.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Light interaction with biomaterials is the driving mechanism of fundamental biological processes, from photosynthesis to DNA photodamage, and is a powerful tool in biomedicine for analytical, diagnostic and therapeutic purposes. The main goal of LightDyNAmics is to achieve a complete understanding of the ultrafast dynamical processes at the molecular scale induced by UV light absorption in DNA, and to unveil the mechanisms leading to photodamage of the genetic code. At the same time, our project will transfer this knowledge on light-matter interaction to a broad class of optoelectronic materials, highly relevant for Europe`s high-tech industries.LightDyNAmics is an academia-industry research environment training 15 Early Stage Researchers (ESRs) by crossing the traditional border between theoretical and experimental expertise. This will be achieved by performing independent, yet interrelated and complementary research projects focussed on photoactivated dynamics of DNA, and by developing a variety of new spectroscopic and computational methods. For all the ESRs, personalised training in advanced techniques will be combined with a broad common interdisciplinary background on dynamical processes in bio-macromolecules. The consortium brings together 10 leading academic groups with multidisciplinary expertise (chemistry, physics, biology) and a unique blend of experimental and computational skills. 6 innovative companies, from SMEs specialised in click-chemistry and in biosensors to a pharma industry, will be fully integrated in the research and training programme and help promote technological exploitation of its results.LightDyNAmics will develop innovative molecular probes for DNA/protein interaction, paving the way to new diagnostic tools and new drugs. The understanding of light interaction with organic molecules will impact on basic sciences, from biochemistry to nanosciences, and on industrial applications ranging from healthcare to photonic technologies.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз