H2020Докторантска мрежа2017–2021

CITYCARE · Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2017-09-01 → 2021-08-31
Финансиране от ЕС: 773 848 €
Участници: 4
Схема: MSCA-ITN-EID

Линиите свързват координатора с партньорите.

Накратко на български

Въздействието на озона, цигаретния дим и дизелните изгорелища върху кожата се анализира в комбинация с UV лъчите. Това помага да се разберат причините за преждевременното стареене и кожата да се защити по-ефективно от градското замърсяване.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Impact of air pollutants on cutaneous responses in both healthy and compromised skin barrier, and innovative solutions to protect skin against urban pollution

The skin is the first barrier against the external environment. Hence, it is constantly exposed to oxidative stress from pollutants such as ground level ozone (O3), particulate matter, cigarette smoke and solar radiation. Those pollutants have severe impacts on skin, including premature skin aging and cancer, as well as may aggravate skin diseases such as eczema, psoriasis and urticaria. The CITYCARE project aimed at better understanding the effects of air pollutants on both skin barrier integrity and function by investigating the synergistic effects of air pollutants such as ozone, cigarette smoke and diesel exhaust with UV radiation. Since the percentage of the world’s population being urban is continuously increasing, there is an urgent need to protect every single city dweller from urban pollution. Although the use of sunscreens in skin care formulations provides an essential protection against the cutaneous damages caused by UV radiation, there was at the time of the project not a single class of compounds that were identified to protect skin against the whole spectrum of environmental stressors. For this reason, an important part of the project included the study and the testing of innovative solutions to protect skin against those air pollutants using both antioxidant compounds and film forming polymers as protective approaches.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Nowadays, our skin is increasingly more assaulted, as a result of the increasingly complexity of our living environment. Because of its critical location, the skin is continuously exposed not only to natural environmental stress factors, such as UV radiation, ozone and extreme weather conditions associated with climatic changes, but also to pollutants/aggressors of anthropic origin, such as cigarette smoke and diesel/gasoline fuel exhaust. By combining the complementary expertise of the three partners involved in the present consortium, i.e. polymer technology and formulation expertise (DCE), skin barrier understanding and biochemistry/molecular biology (UoF), and impact of diesel/gasoline exhaust on cellular responses (UNIFR), this project will aim (i) at better understanding the consequences of air pollutants on both skin integrity and function, (ii) at investigating the synergistic effects of air pollutants such as ozone, cigarette smoke and diesel exhaust with UV radiation, (iii) at discovering innovative solutions to protect skin against those environmental stressors using both a curative approach based on the optimization of the delivery and efficacy of antioxidant compounds, and a preventive approach, based on the formation of a polymeric barrier film at the skin surface, (iv) at studying the impact of air pollutants on both healthy skin and compromised, damaged skin since the number of individuals suffering from skin diseases such as atopic dermatitis and psoriasis continuously increases with the increasingly level of air pollution and air-conditioning systems. The variety of training offered under this EID proposal will enable three early-stage researchers to build strong S&T background as well as to develop numerous transferable skills for their future career. The present training program will allow the researchers to expand their knowledge to new domains and applications, while also providing good networking opportunities.

Оригинален текст от CORDIS (на английски).

Участници

DOW SILICONES BELGIUM · SeneffeКоординаторБелгия
BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY · STANFORDСъединени щати
UNIVERSITA DEGLI STUDI DI FERRARA · FerraraИталия
UNIVERSITE DE FRIBOURG · FribourgШвейцария