Меню
КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2018–2022

EvoCELL · Animal evolution from a cell type perspective: multidisciplinary training in single-cell genomics, evo-devo and in science outreach

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2018-01-01 → 2022-06-30
Финансиране от ЕС
3 784 636 €
Участници
10
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Еволюцията на клетъчните типове при гръбначните и безгръбначните се проучва чрез секвениране на РНК, за да се разбере как се появяват нови видове клетки. Това помага да се установи как се развиват животните и как се формират стъбновите или нервните клетки.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Animal evolution from a cell type perspective: multidisciplinary training in single-cell genomics, evo-devo and in science outreach

Throughout the evolution of animals, the cells that compose their bodies have become increasingly diverse; each cell type is distinguished by the unique set of genes it expresses. The processes by which cells acquired such diverse roles remain poorly understood. Currently, we do not even know how many distinct cell types animals possess, how new cell types arise in evolution, how many are in common between different animal groups, and how many unique cell types have evolved in different animal lineages. Composed of a network of 12 laboratories spread across Europe, EvoCELL studied these fundamental questions in animal evolution and development through extensive use of single-cell RNA sequencing (scRNA-seq). EvoCELL’s scientific aim was to characterize and compare different cell types and tissues in a diverse array of vertebrates and invertebrates showing broad phylogenetic coverage. We sampled data from all major animal lineages and developed new tools for data analyses, through which we pioneered three branches of cell evo-devo: the evolution of stem cells; the emergence of animal life cycles, and the diversity of neural cell types. The EvoCELL network also had a strong focus on science communication. We aimed to find new solutions to exhibit highly complex and contemporary science and so successfully developed the virtual exhibition “Life: through the looking glass” which showcases the research of EVOCELL by emphasizing the procedural nature of science. EvoCELL harnessed and expanded European excellence's world-leading expertise in evo-devo and single-cell genomics by training a new generation of multidisciplinary scientists skilled in exploring the vast breadth of animal differentiation. Over the course of 4 years, the EvoCell fellows acquired highly advanced and diverse scientific skills (single-cell biology and paleontology to bioinformatics) that enhanced their career prospects. Also, they were equipped with outreach and many other complementary skills for a variety of future careers across sectors.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

One of the first events in the evolution of multicellular animals was the differentiation of cells into distinct types with different roles. Starting from their most simple multicellular ancestors, the cells that compose animal bodies have become increasingly diverse; each cell type distinguished by the unique set of genes it expresses. This increase in diversity of cell types over evolutionary time is recapitulated in the process of development during which a single undifferentiated cell - the fertilised egg - divides and its progeny differentiate into the countless cell types of the adult body. Currently we do not even know how many distinct cell types animals posses, how new cell types arise in evolution, how many are in common between different animal groups and how many unique cell types have evolved in different lineages. Our aim in EvoCELL is to lay the foundation for a new branch of evo-devo focussing on cell types. We will study these fundamental questions in animal evolution and development using a new technology - single cell sequencing - which we will for the first time employ outside of lab models to sample the great diversity of animal phyla. Europe is home to world-leading expertise in evo-devo and single-cell genomics, but research and training efforts are as yet uncoordinated and their potential for synergy underexplored. EvoCELL will harness and expand this European excellence by training a new generation of multidisciplinary scientists skilled in exploring the vast breadth of animal differentiation. We will jointly sample data from all major animal lineages, richly represented in the biodiversity of European waters, and develop new tools for comparative analyses, through which we will together pioneer three branches of cell evo-devo: evolution of stem cells; emergence of animal life cycles, and the stunning diversity of neural cell types.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз