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H2020Докторантска мрежа2017–2022

NEUROSOME · EXPLORING THE NEUROLOGICAL EXPOSOME

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2017-10-01 → 2022-03-31
Финансиране от ЕС
3 427 305 €
Участници
15
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Връзката между генетичната предразположеност и вредните влияния от околната среда, като химикали или микроби, върху развитието на детския мозък се анализира тук. Това помага за по-доброто разбиране на причините за невроразвитийните нарушения и подобряването на общественото здраве.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

EXPLORING THE NEUROLOGICAL EXPOSOME

What is the problem/issue being addressed? The impact of prolonged exposure to apparently non-toxic doses of neurotoxicants during early development may have on children’s health, represents a major risk factor for neurodevelopmental disorders (NDs). The etiology of most NDs is unknown, but there is general agreement that they result from complex interaction between multiple genes conferring vulnerability and adverse environmental factors. Exposures, whether chemical, physical, or microbiological, may act directly upon neural cells or may affect the expression of genes that regulate relevant fetal/infant processes. They operate during sensitive periods of gestation by disrupting endocrine systems and altering the hormonal milieu necessary for fetal brain development. Moreover, environmental exposures could contribute to a dysregulated immune system that interacts at the molecular level with glial cells and astrocytes, creating a neuroinflammatory condition. Why is it important for society? NEUROSOME aims at protecting public health against neurodevelopmental disorders using the latest advances in environmental health science, namely the exposome paradigm. The project and its methodological advances are expected to have a positive impact on local society and the economy contributing to more cost-effective environmental management, enhanced human health and reduced costs associated to the health burden from exposure to neurotoxicants. What are the overall objectives? NEUROSOME aims to explore the environmental causes of neurodevelopmental disorders and their complex interplay with genetic predisposition and susceptibility. This will be done by developing a functional link between human biological monitoring and data on exposure to specific environmental compounds and NDs using the latest advances in environmental health science, namely the exposome paradigm. The goal is the development of functional links among the different components of environmental, exposure, Human Biomonitoring (HBM), toxicological and epidemiological studies to understand the causal associations between exposure to organic compounds and metals to NDs. The project’s training goal is to produce a new generation of exposome researchers, trained in academia, applied research and industry, with transdisciplinary skills (environmental end exposure modelling, HBM, -omics technologies, high dimensional bioinformatics and environmental epidemiology,) and understanding of fundamental science and its direct application to environmental health challenges.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The main objective of NEUROSOME is to develop an integrative biology-based framework starting from human biomonitoring data to unravel causal associations among the genetic predisposition, cumulative exposure to multiple environmental chemicals and neurological disorders. The project brings together beyond- the-state-of-the-art advances in human biomonitoring and systems biology, exposure monitoring and toxicological testing technologies and advanced tools for computational analyses of the exposure-to-health effect continuum following an exposome paradigm. The NEUROSOME methodology will be applied in population studies across different exposure settings to neurotoxicants (metals and persistent organics) in Europe. This will improve scientific knowledge on cause and-effect relations between environmental stressors and neurodevelopmental disorders taking into account exposure and health effect modification due to intrinsic (e.g. genetic susceptibility) and extrinsic (e.g. diet and socioeconomic status) factors. New standards for human biomonitoring data interpretation in conjunction with environmental and exposure information will be developed for ready use in chemical mixture risk assessment.The training goal is to produce a new generation of exposome researchers, trained in academia, applied research and industry, with transdisciplinary skills (environmental end exposure modelling, human biomonitoring, -omics technologies, high dimensional bioinformatics and environmental epidemiology,) and understanding of fundamental science and its direct application to environmental health challenges. To this aim NEUROSOME will focus on the provision of trans-disciplinary research training to young researchers through a combination of network-wide training programs and individual personalised training-through-research projects to deliver to the EU and the world a new cohort of researchers trained in cutting edge transdisciplinary environmental health sciences

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз