H2020Индивидуална стипендия2018–2020

EXOGENESIS · Syntenin-phosphatidic acid interaction in exosome biogenesis and cell-cell communication: a structure-function based approach

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-12-01 → 2020-11-30
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Екзозомите са малки мехурчета, чрез които клетките си предават информация, а проектът изследва как мазнината фосфатидна киселина контролира създаването им. Разбирането на този механизъм помага за разработването на нови химични инхибитори за лечение на системни заболявания, включително рак.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Syntenin-phosphatidic acid interaction in exosome biogenesis and cell-cell communication: a structure-function based approach

Exosomes are small extracellular vesicles of endosomal origin that play an important role in cell-cell communication and in the progression of many systemic diseases, including cancer. The aim of this study was to show whether and how phosphatidic acid (PA), a lipid produced by the enzyme phospholipase D2 (PLD2), controls the biogenesis of exosomes. This study aimed to a better mechanistic understanding of the production of exosomes and to help the rational design of new therapeutic chemical inhibitors.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cells communicate with their environment in various ways, including by secreting vesicles. Some of these extracellular vesicles originate from endosomes, are loaded with proteins, lipids and RNAs and are called exosomes. Exosomes emerge as important players in physiological cell-cell communication, but also in various systemic diseases. Understanding how cells control the selective incorporation of ‘messages’ in their exosomes is thus essential, and such fundamental new knowledge may allow us to better understand cancer spread for example. Recently syntenin, a small intracellular adaptor protein, was identified as essential for the biogenesis of presumably a distinct class of exosomes that might be important for cancer cell communication and systemic invasion. Based on preliminary work, this study aims to evaluate the role of the membrane lipid phosphatidic acid in the formation of syntenin exosomes, their loading with cargo and their function in intercellular communication. A structure-function based approach is used, allowing if successful to pave the way for rational and innovative drug intervention. The fellowship will offer the applicant the possibility to receive an intensive training in biochemistry, cellular, molecular biology and drug discovery as well as to acquire important secondary skills which will pave the way for his career as an independent researcher.

Оригинален текст от CORDIS (на английски).

Участници

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE · ParisКоординаторФранция