UPRECON · Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-08-01 → 2020-07-31
- Финансиране от ЕС
- 134 462 €
- Участници
- 2
- Схема
- MSCA-IF-EF-RI
Линиите свързват координатора с партньорите.
Накратко на български
Лазерни методи се изследват за откриване на токсични протеинови структури, свързани с болести като Алцхаймер и Паркинсон. Ранната диагностика преди появата на симптоми е важна за подобряване на здравето и лечението на пациентите.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Ultrafast photonics for the detection and recognition of toxic spine-structures of amyloid aggregates linked to neurodegenerative disease
Neurodegeneration becomes one of the most commonly diagnosed dysfunctions with no certain cure or successful therapy. Projections indicate that, by 2050 over 150M people will be suffering. Neurodegenerative diseases have a greater chance of affecting individuals with the age of 65 years or older. The final product which is a fibrillar structure of the protein is often found in the form of plaques in brains of persons having Parkinson’s, Alzheimer’s, frontotemporal dementia (FTD) and many other neurological diseases. Disease development is related to molecular machinery where mistakes in protein functioning lead to misfolding and aggregation. The consensus is that neurodegeneration starts years before clinical symptoms occur when smaller oligomers start to aggregate. It is accepted that formation of the specific oligomer structures may cause toxicity in terms of neurodegeneration progression. Photonics technology has the accurate sensitivity for early stage amyloid aggregates detection and light can be used to penetrate non-invasively the tissue. That can be used for diagnostics for patients with mild cognitive problems. The UPRECON project was relevant to human medicine for the diagnosis and successful treatment of neurodegenerative diseases in an increasingly aging population worldwide and particularly in developed countries. Finding non-invasive methods for detection of early stage neurodegeneration before clinical symptoms occur is critical for longevity in good health. The idea of the project was to examine laser-based methods that could be developed as diagnostic tools that will not be harmful to patients since the applied light will be in the optically transparent window for living organisms. The overall objectives were focused on detecting early stage amyloidic structures. The key questions were how to develop diagnostic tools capable of detecting structures prone for neurodegeneration and possibly how to differentiate the toxic species by using photonic methods.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Projections indicate that, by 2050, every person aged 85 years or more will be diagnosed with a cognition-related disease. While there is currently no clear strategy for curing such diseases, there are promising developments in the early diagnosis of disease and the inhibition of worsening symptoms. Building on results obtained during my post-doctoral work regarding laser technology for amyloid aggregates detection, I propose to use an advanced ultrafast spectroscopy for structural analyses of the peptides and proteins that form the different fibril architectures in the brains of patients with pathogenic aggregates. In combination with multiphoton absorption, this laser technique has the potential to detect and diagnose in a non-invasive modality the early forms of toxic oligomeric intermediates in the brains of persons with suspected Alzheimer´s or Parkinson´s disease. This methodology has potentially enormous benefits for patients and society. Importantly, the proposed approach of using high-intensity light in the infrared region of absorption does not damage cells and tissues during long-duration irradiation, it does not require the use of chemical labels, and it reduces the need for surgical intervention, as it is non-invasive and safe for human health. I will transfer the knowledge and expertise on biophotonics of amyloid fibrils to Europe and the Host laboratory at the Polish Academy of Science will provide me with advanced training in time-resolved ultrafast laser spectroscopy and access to newly designed setups, as well as supplementary career path-specific training in ancillary skills.
Оригинален текст от CORDIS (на английски).
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Данни: CORDIS, © Европейски съюз