H2020Обмен на изследователи2018–2024

CROSS-NEUROD · Transferring autonomous and non autonomous cell degeneration 3D models between EU and USA for development of effective therapies for neurodegenerative diseases (ND)

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-06-01 → 2024-03-31
Финансиране от ЕС: 594 000 €
Участници: 4
Схема: MSCA-RISE

Линиите свързват координатора с партньорите.

Накратко на български

Общите генетични и молекулярни механизми при болести като деменция и Паркинсон се анализират чрез 3D модели на клетки. Разбирането на тези процеси помага за разработването на нови стратегии за лечение на невродегенеративните заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Transferring autonomous and non autonomous cell degeneration 3D models between EU and USA for development of effective therapies for neurodegenerative diseases (ND)

Neurodegenerative diseases (NDs), including dementia, Parkinson's, and motor neuron diseases, represent a significant and growing challenge in global healthcare. These conditions are particularly devastating for patients and their families. Despite extensive research, decisive cures remain elusive. This is largely due to the insufficient understanding of the pathogenic mechanisms underlying NDs. Addressing NDs is crucial due to their severe impact on individuals’ quality of life, the increasing prevalence as populations age, and the substantial healthcare burdens they impose. Improved understanding and innovative treatments are urgently needed to alleviate both personal and societal costs. The CROSS-NEUROD program aimed to elucidate common cellular and molecular pathways in NDs, exploring both autonomous and non-autonomous mechanisms. By leveraging advanced three-dimensional (3D) cell culture systems, our project aimed to uncover shared genetic and molecular mechanisms across different NDs. This approach is pivotal in identifying potential targets for therapeutic intervention. Throughout the project, we identified critical pathways and genes that are consistent across various NDs, with a particular focus on post-translational protein modifications such as sumoylation and prenylation, and specific genes like STMN2. These findings are promising due to their potential translational impact on the development of new treatment strategies for ND patients. The elucidation of these shared mechanisms in human-relevant models establishes a foundation for future therapeutic advancements, potentially leading to effective prevention and treatment options for a spectrum of neurodegenerative conditions.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Neurodegenerative diseases (NDs), such as Dementia, Parkinson’s and motor neuron diseases, are a major and continuously growing worldwide health issue, particularly devastating for patients and their families. Yet, no cures are available, largely due to the lack of knowledge of ND pathogenic mechanisms. Strikingly, co-occurrence of several NDs in the same patient or family, and evidence that mutations in the same gene lead to several NDs are indicating that common molecular pathways are involved across NDs. Elucidating these shared mechanisms could have a major impact for the treatment and the prevention of this spectrum of NDs. Leveraging on our expertise in studying autonomous and non-autonomous mechanisms of NDs, we propose an innovative, multinational and multidisciplinary collaborative research project to perform network analyses across NDs and identify key common underlying mechanisms. The CROSS-NEUROD project is focused on: 1) the development of integrative in vitro 3D disease models (mini-brains, mini-spinal cords, and motor unit) to elucidate common cellular and molecular pathways across NDs; 2) the validation in animal models of the therapeutic targets identified. To achieve these aims we will consolidate research partnerships through staff exchanges and networking activities between 3 European research organizations, two of which from Italy, one from Greece, and a partner, USA. The project is based on a 4 years coordinated joint program of exchanges of researchers for short periods. It has been developed from active bilateral cooperation between individual countries and partners and represents the natural progression of our previously funded and successfully completed EU 7PQ IRSES grant “No-MND” (2013 call). Our ongoing research programs are well supported by funding. The RISE scheme provides a unique opportunity to integrate ongoing collaboration activities into a coherent program addressing an issue of high priority for public health both in EU and USA.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITA DEGLI STUDI DI MILANO · MilanoКоординаторИталия
FONDAZIONE IRCCS CA' GRANDA - OSPEDALE MAGGIORE POLICLINICO · MilanoИталия
IDRYMA IATROVIOLOGIKON EREUNON AKADEMIAS ATHINON · AthinaГърция
TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK · New YorkСъединени щати