RAMAN-Dx · Raman spectroscopy for early diagnosis of oral pre-cancer and cancer using minimally invasive samples

Raman spectroscopy for early diagnosis of oral pre-cancer and cancer using minimally invasive samples

In 2018, there were an estimated 354,864 cases of lip, oral cavity and pharyngeal cancers and the incidence and a mortality of 177,384. The 5 year survival rate for oral cancer for Europe is only 50% and patients often present with advanced disease. Multiple primary tumours and field cancerization are common and there is a high risk of developing secondary tumours. Therefore, it is of paramount importance to diagnose the disease early. Diagnosis of oral pre-cancer and cancer starts with conventional oral examination by the clinician followed by biopsy and histopathology. This is regarded as the gold standard but is subjective and depends upon visual examination so sensitivity and specificity can be poor at the early stages of the disease. Hence, there is a significant need for new diagnostic techniques to detect pre-malignant lesions. The overall objective of this project was to develop new methods based on Raman spectroscopy for probing biochemical changes associated with oral pre-cancer and its progression. During the project, a comprehensive time-gated Raman spectral library containing high-quality Raman spectra measured from oral samples from patients and normal subjects was established. Furthermore, a SERS spectral library of salivary samples was developed. In addition to training through research, the MSCA fellow was trained in transferable skills such as project management, communication skills, networking, ethics, gender equality and IPR management.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз