H2020Индивидуална стипендия2018–2020

BRONC · Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-11-01 → 2020-10-31
Финансиране от ЕС: 187 420 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Невронните мрежи в мозъка на мишки се променят динамично, например когато животните използват езика си, за да сигнализират за допир с мустаците. Това помага да се разбере как фиксираните анатомични връзки позволяват гъвкаво поведение и адаптация към различни ситуации.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

We can change our thoughts and behavior flexibly to survive in the changing world. However, it remains to be elucidated how our brain achieves such flexible behavior. The goal of this project has been to uncover the mechanisms of such behavioral flexibility from a view point of neural circuits. Mammalian brain is subdivided into functionally differentiated small areas. The brain areas are anatomically connected by the axon fibers of neurons to communicate information. The anatomical connections are mostly fixed through the development, and do not change in adulthood. But adult animals can still behave very flexibly depending on different situations, and do not necessarily show a stereotypical response even when they encounter the same object. To enable such flexible behavior with the fixed anatomical connections, one possible way would be to modify the efficiency of the communication among brain areas to form a tailored circuit for behavior on demand. To examine such a possibility, I studied the brain of mice learning and executing a behavioral task where they reported whisker tactile perception by tongue movements, and revealed that the communication among brain areas was selectively enhanced and suppressed to form a temporary circuit executing necessary computation in the task context. The achievement of this project founded an important basis to further investigate the detailed mechanisms of rapid modification of brain circuits.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

CAREER PLAN:The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain. INTRODUCTION:We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.OBJECTIVE:Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action.2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm.3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

Оригинален текст от CORDIS (на английски).

Участници

ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE · LausanneКоординаторШвейцария