H2020Индивидуална стипендия2018–2020

BESIDE · Bile acids and epithelial stem cells in intestinal development

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-04-01 → 2020-03-31
Финансиране от ЕС: 175 866 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Бактериите в червата и техните ензими влияят върху развитието на стомашно-чревния тракт, като например променят жлъчните киселини. Разбирането на този процес помага да се обясни появата на дългосрочни заболявания като астма и атопични дерматити.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Bile acids and epithelial stem cells in intestinal development

BESIDE investigated the effect of secondary bile acids on gut maturation during the first stages of life at APC Microbiome Ireland. The preliminary data from this project showed exciting and potentially groundbreaking results. The gut microbiota, which is a complex community of microorganisms (bacteria, viruses, and fungi) that inhabit our gut, have key functions in our body including the development of the immune system, metabolisms and maturation of the gastrointestinal tract (GIT). The establishment of the gut microbiota starts at birth and develops over time coinciding with the maturation of the GIT suggesting that these early microorganisms and the compounds they produce may have an impact on gut development. Bile acids, the principal components of bile are released into the intestine to aid in the digestion of fats and vitamins. These bile acids are released conjugated to amino acids (primary bile acids), which are known to be toxic to bacteria. Some microorganisms of the gut are able to break the bile acids down through activity of a bacterial enzyme called bile salt hydrolase (BSH). These BSH positive bacteria have an impact on physiological processes and they also belong to some of the first colonizers of the GIT suggesting that BSH activity may have a crucial effect in the gut development and maturation. This project investigated how bacteria with this BSH activity influence the development of the GIT. The presence of microorganisms in the gut during the early stages of life is a critical event in the normal development of the GIT. Imbalances in the microbiota in early life have been linked to the development of long-term disorders (including asthma, atopic disease, and necrotising enterocolitis). Given the huge cost of treating these diseases, the preliminary results could have major implications for public health strategies because correcting imbalances in early development of the microbiota (through bacterial or biochemical interventions) could provide new modalities to treat or prevent a range of disorders. Some highlights from the BESIDE project included being nominated and selected as a representative of the EU MSCA programme to attend the 70th Lindau Nobel Laureate Meeting and being hired immediate afterwards by the Centre for Research in Vascular Biology.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This project will investigate how gut bacteria (the microbiota) influence development of the human gastrointestinal tract (GIT) through innovative research at a world leading research centre (the APC Microbiome Institute) and secondment to the R&D division of a leading multinational biotech company (Perkin Elmer). The gut microbiota comprises a complex community of microorganisms that provide essential metabolic functions in the host. The colonisation of the gut begins during the antenatal period, continues after the moment of birth and is coincident with rapid morphological and functional gut maturation suggesting that these early colonisers and their metabolites have an impact on GIT barrier development. Bile salt hydrolase (BSH) activity (which deconjugates amino-conjugated bile acids in the gut), is present among the first colonisers of the GIT. Thus, the BESIDE project hypothesis is that this bacterial BSH activity critically affects GIT development and maturation in early life. To understand the mechanisms underlying this relationship, BESIDE will conduct a series of experiments to i) determine how BSH activity influences intestinal stem cells (IESCs); ii) identify the effects on proliferation of these IESCs and iii) extrapolate the obtained results using an in vivo model. BESIDE presents a novel approach using methods based on cutting-edge cell culture, flow cytometry and cell imaging to gain knowledge which is likely to inform the future development of therapeutics to improve barrier function in the neonate. Additional objectives of BESIDE include dissemination and transfer of knowledge to relevant stakeholders (as well as to the general public) and the development of management and career development skills. This, in line with the Work Programme for the MSCA fellowship, will help the applicant to become an independent professional scientist in the field so that she will continue to make significant contributions to the European society and economy.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK · CorkКоординаторИрландия