H2020Индивидуална стипендия2018–2020

BiHyOMat · BioHybrid Optoelectronic Materials

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-06-01 → 2020-06-20
Финансиране от ЕС: 191 326 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Биохибридни материали, съчетаващи протеини и светлочувствителни молекули, се разработват за създаване на сензори и фотодинамична терапия. Тези структури помагат за подобряване на пречистването на отпадните води и медицинските приложения.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

BioHybrid Optoelectronic Materials

BiHyOMat is an ambitious research at the interface of chemistry, physics and biology, aiming to produce novel high-end materials for medical and environmental applications. The reversible conjugation of proteins and light absorbing molecules will combine the biocompatibility and defined structure of the former with the light-induced properties of the later. In particular, fluorescence and generated of reactive oxygen species have extensive application in sensors, photodynamic therapy or waste-water treatment. The overall objectives are: - Develop and validate new synthetic approaches towards monodimensional protein aggregates. This morphology will enhance the contact with the media, increasing the efficiency of the material. - Create novel morphologies as scaffold to conjugate with magnetic nanoparticles or create metal nanoparticles. The BiHyOMat project yielded three publications in high impact factor journals, exploring the preparation of anisotropic biohybrids with optical properties. The scientific output has generated the initial drive for a promising scientific career for the researcher. The action provided the necessary tools for career development: a wide and multidisciplinary collaboration network, teaching skills, group management and public outreach.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

BiHyOMat is an ambitious research project at the interface of chemistry, physics and biology, with the aim to produce high-end optoelectronic materials. To this end, the project will take advantage of the co-crystallization of toroidal proteins and photosensitizers into monodimensional self-assemblies by means of electrostatic interactions, being a field where the hosting group is playing a pioneer role. By means of pH, temperature and electrolyte control, different proteins and dyes will be conjugated to a wide variety of materials with different stabilities and optical properties. Peroxiredoxin, an ubiquitous protein with a wide selection of isoelectric points has been selected as protein scaffold of the columnar stacks, along with a selection of charged phthalocyanines and porphyrins playing a dual role as molecular glue and photoactive moieties. The latter group will be obtained through collaborations, commercial sources or synthesized by the candidate.The resulting materials will be thoroughly characterized by a broad selection of techniques, including cryo-TEM, SAXS and time-resolved spectroscopy. Additionally, the spectroscopic properties arising from the anisotropic array of dyes into this well-defined structure will be thoroughly explored. Furthermore, the resulting tubular arrays will be conjugated supramolecularly with magnetic nanoparticles, endowing them with magnetoresponsive behaviour. Finally, the tubular aggregates, presenting a well-defined inner pore, will be employed as nanoreactors to synthesize finely tuned rod-like nanoparticles, taking advantage of the hollow structure of the stacks.

Оригинален текст от CORDIS (на английски).

Участници

AALTO KORKEAKOULUSAATIO SR · EspooКоординаторФинландия