ElectroNick · The Combination of Electrochemistry and Nickel Catalysis: New Bond-Forming Reactions on a Sustainable Platform
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-05-01 → 2021-04-30
- Финансиране от ЕС
- 239 191 €
- Участници
- 2
- Схема
- MSCA-IF-GF
Линиите свързват координатора с партньорите.
Накратко на български
Електрохимични реакции с никелови катализатори се използват за създаване на нови връзки между въглеродни атоми. Това помага за по-ефективен синтез на лекарства и земеделски препарати, като намалява количеството метални отпадъци.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
The Combination of Electrochemistry and Nickel Catalysis: New Bond-Forming Reactions on a Sustainable Platform
Throughout the design of new molecules for pharmaceutical and agrochemical applications to benefit society, the formation of carbon–carbon bonds represents a key strategy to combine chemical groups together. However, many of these methods use metal atoms, which become waste at the end of the reaction. To overcome this, chemists use catalysts which can produce multiple equivalents of the new carbon–carbon bond for every molecule of metal catalyst, improving the efficiency and sustainability of the reaction. In particular, electrocatalysts have recently become an important tool towards sustainability in organic chemistry reaction design, using a cheap and efficient supply of electricity to drive the reaction and limit waste. To this end, ElectroNick aims at establishing a suite of new electrocatalytic carbon–carbon bond formation reactions using nickel complexes as efficient catalysts for synthesis. Reactive intermediates can be forged within the reaction mixture, limiting the waste of metals such as zinc and cobalt. Not only will these reactions improve sustainability in organic synthesis, they will provide the possibility of designing the synthesis of new carbon–carbon bonds with high efficiency and selectivity. However, in order to design these new catalytic systems, it is important to build a deep understanding of the multiple steps within each catalytic cycle, and how subtle changes in the metal complex or substrates that form the new carbon–carbon bond affect overall reactivity. ElectroNick has utilized cutting-edge techniques in electroanalysis and ‘big data’ science to understand these intricate effects, and employed the knowledge gained through these processes in developing new reactions for carbon–carbon and carbon–heteroatom bond formation.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Sustainable routes towards the formation of key synthetic carbon–carbon bonds by cross-coupling remains a challenge in organic chemistry. Realization of this goal will enable the combination of simple building blocks to rapidly assimilate synthetic complexity with only a minimum level of stoichiometric waste. Electrochemistry provides a new platform to conduct reactions through in situ generation of reactive intermediates under mild conditions, with broad applications to industrial synthesis. Herein, we seek to combine the fields of electrochemistry and cross-coupling reactions, using an electric current to catalytically generate alkylzinc reagents and reactive alkyl radicals. These intermediates will then undergo coupling, facilitated by nickel catalysis, to generate key carbon–carbon bonds, including challenging C(sp3)–C(sp3) bonds. Furthermore, the powerful combination of electrochemistry and nickel catalysis will enable the simplest feedstock chemicals – alkanes – to be utilized for the first time in cross-coupling through a nickel chain-walking process, providing facile access to fatty acids and alternative coupled products. These projects will enable the emergence of new reaction strategies for exploitation in a sustainable manner. Additionally, this ambitious and innovative proposal will succeed through considerable two-way transfer of knowledge between the participating organizations and the ER, developing the fellow into a leading international researcher.
Оригинален текст от CORDIS (на английски).
Участници
- FUNDACIO INSTITUT CATALA D'INVESTIGACIO QUIMICA · TARRAGONAКоординаторИспания
- UNIVERSITY OF UTAH · Salt Lake City UtahСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз