ORO · A General Strategy for the Generation and Use of Oxygen Centered Radicals in Organic Synthesis
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-09-01 → 2020-08-31
- Финансиране от ЕС
- 195 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Нови методи за синтез на органични съединения чрез видима светлина ще помогнат за създаването на хетероцикли и функционализиране на ароматични вещества. Тези процеси помагат за разработването на следващо поколение лекарства, хранителни добавки и устойчиви материали.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
A General Strategy for the Generation and Use of Oxygen Centered Radicals in Organic Synthesis
• What is the problem/issue being addressed? This project aims at addressing two key questions: 1. Development of novel visible-light-mediated catalytic methods for the assembly of heterocycles 2. Development of novel visible-light-mediated catalytic methods for the functionalization of aromatics • Why is it important for society? Organic chemistry is integral to the weel-being of our society. It is thorugh by inventing and the developing new reactions that we can identify the next generation of drugs, agrochemical, food additives and organic materials. From this perspective the use of visible-light to promote these reactions might offer great opportunities in terms of sustainability. • What are the overall objectives? 1 Develop novel approaches for the preparation small heterocycles 2 Develop novel multicomponent reactions via radical species. 3 Develop a novel approach for the functionalization of aromatics
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Oxygen-containing molecules are widespread as medicines, agrochemicals, organic materials, perfumes and dyes. Their preparation could be greatly facilitated by implementing oxygen-radicals, which are a class of very versatile synthetic intermediates. However, to date, difficulties associated to their generation have severely limited their use and exploitation in synthetic settings. Here we propose the development of two conceptually novel and general ways to prepare oxygen-radicals using visible-light. These processes will capitalize on recent developments in the host group that has disclosed two novel organocatalytic ways for the generation of nitrogen-radicals. This proposal seeks to substantially expand this photochemical approach by developing unprecedented methods for the generation and use of oxygen-radical. The power of this approach will be demonstrated by fast generation of 3D molecules containing multiple atoms of oxygen. These methods will be then integrated with other reaction platforms that, taking advantage of visible-light as source of energy, will engage the oxygen-radical in new reactivity modes, to allow novel and powerful multicomponent oxo-functionalization reactions. Furthermore, we will harness this activation modes to enable the direct oxygenation of aromatic compounds in a single step without the use of transition metal catalysts.Through the use of this strategy, the rapid construction of many relevant and complex oxygenated molecules will be possible. The development of such an innovative and ambitious project at the University of Manchester will be facilitated by generating, transferring, sharing and disseminating knowledge, and will enhance my career development following the training plan envisioned.
Оригинален текст от CORDIS (на английски).
Участници
- THE UNIVERSITY OF MANCHESTER · ManchesterКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз