HI-SiMed · Hemodynamics in an Infarcted heart: from multi-physics Simulations to Medical analysis
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2019-09-01 → 2021-08-31
- Финансиране от ЕС
- 165 599 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Компютърни модели симулират работата на лявото сърце, включително електрическите сигнали и движението на кръвта след инфаркт. Тези симулации помагат за по-добро разбиране на сърдечните заболявания и избор на подходящо лечение за пациентите.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Hemodynamics in an Infarcted heart:from multi-physics Simulations to Medical analysis
Cardiac disease remains the most common cause of mortality in the industrialized world with risk factors including high blood pressure, smoking, diabetes, lack of exercise, obesity, high blood cholesterol, poor diet, and excessive alcohol intake. Detailed understanding of the heart functioning is fundamental for the improvement of diagnoses and therapies. In this framework, computational engineering is becoming an added value in medical research since it provides more details on heart pathologies and could predict the most favorable medical treatment. Over the last two decades, indeed, computational engineering has gained credibility and nowadays it is mature enough to produce reliable in silico experiments, which provide potentially unlimited access to hemodynamics data and dynamical features of the system that would be exceedingly difficult or impossible to obtain otherwise. Furthermore, novel technological solutions (prostheses or surgical procedures) can be virtually tested, thus avoiding the extensive use of hardware models or in vivo experiments on animals. On the other hand, a computational model yields a high-fidelity representation of the cardiovascular dynamics only when all the main features of the system are properly considered; these include actively (myocardium) and passively (valves and artery/vein walls) deforming nonlinearly elastic tissues, the electrophysiology of the heart with the propagation of the electrical signal over a complex path, the unsteady (pulsatile) of the blood flow, its non-Newtonian dynamics and the strong interplay among all the systems. With the above motivations, in this project we have developed and validated a multi-physics model of the left heart that can cope with the electrophysiology of the myocardium, its active contraction and passive relaxation, the dynamics of the valves (aortic and mitral) and the hemodynamics within ventricle, atrium and the first tract of the aorta.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The left ventricle is the principal mechanical element of the human heart that propels blood to the systemic circulation. Its contraction is the result of an electrical wave propagation generated at the cellular level and is studied in the framework of cardiac electrophysiology. This science is nowadays mature and provides models to capture and reproduce the contraction/relaxation cycle of the heart that are used for a quantitative understanding of the heart functioning. However, these electrophysiology models do not include the hemodynamics caused by the ventricle deformation, thus neglecting the fundamental vortex dynamics taking place in the heart physiology, which generates stresses on the surrounding cardiac tissue. This project aims at connecting the electrophysiology and the fluid mechanics building an electro-fluid-structure computational model for the pulsatile flow in an animated left ventricle and elastic aorta. Biological heart conditions will be reproduced as close as possible by merging my electrophysiology code with the advanced fluid-structure framework of the Physics of Fluids group (PoF) at University of Twente (UT). The resulting multi-physics model will allow studying the accurate hemodynamics and cardiac tissue stresses generated in an animated ventricle. Building on my experience in vortex dynamics, we will correlate the topology of the vorticity structures with the heart functional pumping and then study how cardiac diseases such as myocardium infarction modify them, accounting for infarction location and sex differences. The outcomes of HI-SiMed will provide the medical community with an innovative and advanced tool that could open new horizons for the improvement of treatment outcomes. With this ambitious aim, the project will be developed in close cooperation with the cardiac surgeons already collaborating with the PoF.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITEIT TWENTE · EnschedeКоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз