INBID · Improving the resolution of Neuroinflammation during repetitive mild Traumatic Brain Injury with dietary fatty acid Derivatives
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-11-01 → 2020-10-31
- Финансиране от ЕС
- 185 076 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Възпаленията в мозъка при повтарящи се леки травми, като удари в главата, се анализират чрез модел с мишки. Разбирането на тези процеси е важно за справянето с депресия, тревожност и болест като Алцхаймер.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Improving the resolution of Neuroinflammation during repetitive mild Traumatic Brain Injury with dietary fatty acid Derivatives
Historically, the two major ‘systems’ of the body were divided into nervous and immune. The former containing the electrical wiring governing our senses and our mind, the latter consisting of mobile defence cells ready to fight infection, disease and injury. Little did we know that our nerves and immune cells are so intertwined that their roles are dependent on one another. Microglia, the brain’s resident immune cells are now known to be involved in a host of brain functions, including development, neuronal function and protection from - or propagation of - disease. Recent evidence also shows that the higher functions of mammalian brains, those that manage emotions such as anxiety, and social behaviour and memory, can even be affected by mobile immune cells that have travelled to the edges of the brain. Here, immune cells do not enter the brain tissue itself, but reside in different structures bordering the brain and release factors that can change the way nerves work, and as a result, how animals behave. In certain circumstances, the brain may become inflamed, due to an injury or disease. This can even happen in ‘mild’ injuries such as a bang to the head, resulting in mild traumatic brain injury or concussion. Concussion affects millions of people world-wide each year due to accidents, assaults, domestic violence, contact sports and war. These injuries increase the risk of developing mental health issues such as long-term anxiety and depression and neurodegenerative diseases such as Alzheimer's. Repeated head injury is particularly dangerous. Therefore, understanding the mechanisms that underpin these problems is critical to treating brain injury and disease. Overall objectives of the work 1) Define the immune-mediated brain inflammation in mouse model of brain injury 2) Develop approaches to promote the resolution of brain inflammation in response to brain injury, with a special focus on dietary lipids as beneficial agents.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Traumatic brain injury (TBI) represents a major health problem in Europe. Repetitive mild TBI (rmTBI) is a particularly dangerous form, due to its prevalence and limited overt clinical signs. This is concerning as rmTBI can lead to cumulative injury and is an established risk factor for dementia. Repetitive mTBI has been referred to as a ‘hidden epidemic’, but little is known about the pathological mechanisms. The project aims to address a major clinical need by identifying and validating new targets for the treatment of rmTBI. Microglia are critical components of neuroinflammation and are promising targets for intervention. It is now understood that nutrition and the amount of polyunsaturated fatty acids (PUFAs) contained within the diet can have profound effects on brain inflammation. Furthermore, specialised pro-resolving mediators derived from PUFAs have shown promise as interventions for disease.We hypothesise that the microglia-mediated inflammatory response to mTBI can be affected by manipulating PUFA levels to reduce the harmful, cumulative effects of a second mTBI. We will use a clinically relevant model of rmTBI in mice and investigate the resolution of inflammation during the period between injuries. These studies will be the first to integrate multiple parameters of microglia-mediated inflammation, combining transcriptomic and lipidomic profiling with unbiased network analysis to describe the resolution of inflammation in mTBI. Finally, by targeting of the most important network parameters, we will attempt to speed up the resolution of inflammation and so reduce the impact of rmTBI. The joinedexpertise of the applicant (neuroinflammation and microglia), the host lab (nutrition, lipids, behavior), and the secondment lab (transcriptomics and microglia) will guarantee the success of the project, validate new targets for the treatment of rmTBI, further the applicant's promising scientific career and bring new tools and approaches to the host laboratory.
Оригинален текст от CORDIS (на английски).
Участници
- INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT · ParisКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз