LowD-CT · Low-dose Computed Tomography for pediatric applications
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2019-03-25 → 2021-03-24
- Финансиране от ЕС
- 166 994 €
- Участници
- 2
- Схема
- MSCA-IF-GF
Линиите свързват координатора с партньорите.
Накратко на български
Нови детектори за броене на фотони и специални алгоритми се тестват за компютърна томография при деца, например за диагностика на сърдечни пороци. Това помага за намаляване на радиационната доза и риска от рак, като същевременно подобрява точността на изображенията.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Low-dose Computed Tomography for pediatric applications
X-ray computed tomography (CT) imaging is an important medical diagnostic technique where a rotating X-ray source and detector are used to image the patient from all directions, allowing a 3D map of the tissue density to be reconstructed. This imaging modality is widely used in the clinic with an estimated 85 million examinations per year in the USA alone in 2012. In children, CT examinations are used for diagnosing congenital heart disease, finding tumors, identifying post-traumatic changes in the brain and planning surgery, among other applications. However, the radiation dose must be kept as low as reasonably achievable to minimize the risk of cancer, in particular for children. One way to lower the radiation dose is to employ photon-counting detectors. This new detector type promises several improvements: lower dose, higher spatial resolution and better measurement accuracy in the images, which is expected to translate to improved diagnostic accuracy and lower cancer risk for the patient. Also, the ability of this detector type to remove beam-hardening artifacts allows them to be used with low X-ray tube voltages (70-100 kV), which is preferable when imaging small patients. These advantages are particularly important for imaging of small children. The purpose of this project is to use the photon-counting silicon-strip detector with a new reconstruction algorithm, combining fast reconstruction time with optimal dose utilization, to show a proof of principle for a new technique: low-dose photon counting CT. To achieve this, the project has the following specific objectives: Objective 1 is to develop a computationally inexpensive reconstruction algorithm for low-dose photon counting CT that makes optimal use of the measured data in terms of low-contrast detectability, spatial resolution and accuracy of the reconstructed CT numbers. Objective 2 is to compare the image quality of low-dose photon-counting CT images to a state-of-the-art CT scanner in clinical use, at equal dose. Objective 3 is to compare the detectability in photon-counting low-dose CT images of phantoms to the detectability of state-of-the-art x-ray radiography images at equal dose. However, when carrying out the action, it was decided to change objective 3 to "Develop a deep-learning based image reconstruction algorithm for material-selective photon-counting imaging and evaluate this method in a simulation study."
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
X-ray computed tomography (CT) is a widespread medical imaging modality with 85 million examinations performed in 2012 in the US alone, but there is a need for improving instrumentation to minimize the potential health risks due to radiation dose. Although the benefits of CT imaging greatly outweigh the risks, the dose must be minimized, especially for children. Using other modalities may not be an option since ultrasonography lacks sufficient diagnostic quality and MRI is time-consuming, expensive and may require sedation of small children.At KTH Royal Institute of Technology, a photon-counting silicon-strip detector that promises better image quality and lower dose than today’s CT detectors has been developed. In the proposed project, this detector will be used to develop a new CT technique for imaging children: low-dose photon counting CT. To this end, a reconstruction algorithm for low-dose imaging will be developed and tested by imaging phantoms. The imaging performance will be compared to current state-of-the art CT and x-ray radiography systems.General Electric (GE) is a market-leading CT vendor with the experience necessary to turn this idea into a product used in the clinic. The applicant will therefore carry out the 12-month outgoing phase at GE Global Research Center, Niskayuna, in close collaboration with GE Healthcare, Milwaukee. During the return phase, the applicant will use the experience gained from GE Global Research for continuing the research into photon-counting CT at KTH. In this way, KTH gains access to the expertise of GE on image reconstruction while GE gets an opportunity to evaluate the feasibility of integrating the photon-counting CT detector into a commercial CT scanner.A successful outcome can have a large impact on children’s health by allowing projection radiography to be replaced by CT and by decreasing the CT radiation exposure by at least 50%, enabling new examinations that are not done today due to radiation safety concerns.
Оригинален текст от CORDIS (на английски).
Участници
- KUNGLIGA TEKNISKA HOEGSKOLAN · StockholmКоординаторШвеция
- GENERAL ELECTRIC COMPANY · BOSTON MAСъединени щати
Връзки
Данни: CORDIS, © Европейски съюз