H2020Индивидуална стипендия2018–2021

MTOAC · Multi-compartmental Tumor-on-a-Chip

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-09-01 → 2021-01-06
Финансиране от ЕС: 185 076 €
Участници: 1
Схема: MSCA-IF-EF-SE

Линиите свързват координатора с партньорите.

Накратко на български

Моделът „тумор върху чип“ имитира средата около рака на гърдата, за да проследи взаимодействието между раковите и съседните клетки. Това помага за разбирането на разпространението на тумора и подпомага разработването на нови лекарства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Multi-compartmental Tumor-on-a-Chip

Breast cancer is the most common invasive cancer among women. There are several chemotherapeutics and radiotherapeutics approaches available but they have certain limitations. Over the past few years, improved understanding of the microenvironment heterogeneity of breast cancer has allowed the development of more effective treatment strategies. However, researchers have still not been able to recapitulate the entire tumor microenvironment to study the tumor progression and invasion. In this direction, the breast tumor-on-chip model has emerged as an alternative system to study the tumor microenvironment and deciphering its role in metastasis. The tumor-on-chip system mimics the exact in vivo condition, by controlling the user defined environmental parameters, mechanical and biological signals generated by neighboring cells. These controlled microenvironmental conditions enable the investigation of the physiological and metabolic changes and cancer-stromal cells interaction which facilitates the formation of tumor microenvironment conditions. In this way, this tumor-on-chip model can be helpful for providing the information related to basic tumor physiology and characteristic features of tumor which helps in tumor migration, and progression. In this way, it will provide a possible therapeutic approach and potentially helps in drug development for cancer therapeutics.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Breast cancer is one of the most common causes of cancer-related death in women all over the world. Although therapeutic approach like surgery, chemotherapy, radiation and targeted therapy reduced the risk of cancer specific mortality. Still there is a risk of cancer recurrence and mortality. Cancer research is typically dependent on 2D system and animal model which leads to conflicting the result due to cellular behavior, phenotypes, gene expression level and expensive animal studies (Szot et al., 2011). In this way 3D microfluidics systems are designed to fulfill the gap between 2D and animal model for screening and testing of drug. The present proposal is conceptualize to bridge the gap between 2D and animal model effectively, by designing the Organs-on-chip (3D), microfluidics system of tumor microenvironment to evaluate the efficacy of combination of anticancerous drug. Herein, the multi-compartment microfluidics platform will be generated by co-culturing of cancer cells, fibroblast and endothelial cells into biocompatible hydrogel, to produce a multi-organ-on-a-chip devices. It recapitulates organ-like functions in each compartment and a vascular-channel between the compartments produce preliminary human on-chip. This 3D microfluidics system dedicated to evaluate the efficacy of anticancerous drug will be helpful to improve the future drug development applications.

Оригинален текст от CORDIS (на английски).

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