CORVISDEC · Cortical circuits underlying visual decision-making behaviors in mice
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-08-01 → 2020-07-31
- Финансиране от ЕС
- 183 455 €
- Участници
- 1
- Схема
- MSCA-IF-EF-ST
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Накратко на български
Невронните вериги в мозъка на мишки се анализират, за да се разбере как визуалната информация се превръща в конкретно действие. Това помага да се разбере как mammals обработват сетивни данни и вземат решения в променяща се среда.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Cortical circuits underlying visual decision-making behaviors in mice
An important part of successfully navigating the world is the ability to make choices within our environment. From a neural standpoint, each decision is a complex synthesis of perceptual, cognitive, and motor processing that transforms sensory evidence about the world into interactions with the environment. However, the neural transformations from evidence to action are still unclear. To better understand the perceptual, cognitive, and motor aspects of decision-making, this project combined a tractable mammalian model (mouse), a high-throughput neural assay (two-photon imaging), and a complex behavioral task (psychophysics) to parse the neural computations required to drive decision-making in a complex and changing environment. Specifically, our objectives for this project were to: (1) Train mice to perform a complex visually guided behavioral task that required mice to transform uncertain sensory evidence and decision history into choice actions; (2) Train animals with an open-source behavioral paradigm and setup that we could deploy to multiple laboratories as part of a global collaboration studying visually guided behavior in the mouse; (3) Once animals were trained in the behavioral task, record activity in the mouse’s brain using two-photon imaging techniques, which afford the longitudinal and large-scale tracking of neurons over multiple brain regions and multiple days; (4) Using data from these recordings, decode the specific task variables from various neural populations to identify which cortical regions are responsible for transforming sensory evidence into motor actions. The project's high-throughput in vivo imaging combined with a complex behavioral task hold promise for disentangling the sensory, cognitive, and motor processing required for mammals to successfully make decisions under real-world conditions. Identifying the cortical role in decision-making will direct neuroscience toward a better understanding of how we interact within complex social environments, and how this process may be disrupted in conditions such as Alzheimer’s disease, autism spectrum disorders, depression, obsessive-compulsive disorder, or drug addiction.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
An important part of successfully navigating the world is the ability to make and act upon choices. In the brains of humans and other mammals, the cerebral cortex is considered an important structure for accumulating sensory evidence and executing actions, but the neural relationship between evidence and action is still unclear. A serial information processing hypothesis posits that cortical areas work in sequence to transform sensory evidence into behavioral choices, while an alternative parallel processing hypothesis argues that multiple, competing sensorimotor signals are combined at the earliest instance. Though there have been many studies of single-cell recordings offering support for one or the other hypothesis, the key to truly understand these complex behaviors will require recording from many hundreds of neurons over many different regions of the brain. In this proposal, I present a plan for a high-throughput assay of decision-making activity in the mouse brain. To compare these hypotheses, I will use two-photon calcium imaging to record simultaneously from thousands of neurons across many areas of cerebral cortex while mice perform a visually guided task that parses the perceptual, cognitive, and motor aspects of decision-making behavior. In analyzing the activity of these very large neural populations, I will be able to identify and distinguish how each cortical region contributes to aspects of the task and overall animal performance. I will further probe the structure of decision-making activity in cortex by introducing an adaptation paradigm to the same task, comparing how perceptual correlates for adaptation are linked to neural correlates, and observing how these effects manifest across different cortical areas.I will perform these experiments in the Cortical Processing Laboratory at University College London, led by Drs. Kenneth Harris and Matteo Carandini.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITY COLLEGE LONDON · LondonКоординаторОбединеното кралство
Връзки
Данни: CORDIS, © Европейски съюз