H2020Индивидуална стипендия2018–2021

SquaMem · Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silico study

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-11-01 → 2021-09-19
Финансиране от ЕС: 173 076 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Лекарства на основата на сквален, като тези срещу рак и вируси, се анализират чрез компютърни модели за взаимодействието им с клетъчните мембрани. Това помага за подобряване на доставката на медикаментите до конкретни клетки и намаляване на страничните ефекти при терапията.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Interaction of squalene-based anti-cancer and neuroprotective drugs with cell membranes: in silicostudy

Squalene is a natural lipid precursor, which plays a crucial role in the biosynthesis of sterols in the cells. It is 100% biocompatible, not toxic and is able to strongly interact with the cells. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called “squalenoylation” technology is based on the conjugation of squalenic acid with a variety of drugs. The resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver efficiently the drugs into the target cells. Currently, anticancer (gemcitabine, doxorubicin), antiviral (dideoxycytidine) and neuroprotective (adenosine) drugs were used in this technology with great success. The next steps of these technology are to improve the ADME (Administration, Delivery, Metabolism and Excretion) profiles of the squalene-based drugs and to provide selectivity to target cells in order to reduce the side effects of therapy. In this project we focused on interaction of squalene-based drugs with the membranes, which is crucial for an effective transport of the drugs into the cells, and their selectivity to the membranes of different composition and curvature, which may serve for targeted delivery and action, especially in oncology for discrimination between normal and cancer cells.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Squalene is a natural lipid precursor, which plays a crucial role in the biosynthesis of sterols in the cells . Squalene is 100% biocompatible, not toxic and is able to enter into the cells easily. This makes it very promising for creating highly efficient drugs and drug delivery systems. The so-called squalenoylation technology is based on fusing hydrophobic squalenic acidwith the molecules of water-soluble drugs. Resulting conjugated molecules spontaneously self-assemble into nanoparticles, which deliver the drugs into the target cells efficiently. Currently anticancer (gemcitabine , doxorubicin ), antiviral (dideoxycytidine ) and neuroprotective (adenosine ) drugs were used in this technology with great success. This project is devoted to revealing mechanisms of interaction of novel and highly promising squalene-based anti-cancer and neuroprotective drugs with cell membranes by means of in silico ccomputer simulations. The main goals of the project are the following:1. To reveal how squalene-based drugs incorporate into the cell membranes, interact with membrane components and are released from the membranes on atomistic level of details.2. To propose the ways of improving translocation of squalene-based drugs through the membranes in order to increase their therapeutic efficacy.The practical impact of the project is improving translocation of squalene-based drugs through the membranes and making it selective, which is of great interest for therapeutic applications of existing drugs and for creation of new compounds with desirable properties.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITE DE FRANCHE-COMTE · BesanconКоординаторФранция