MetaBioMec · Biomechanics of menisci: a multiscale experimental, theoretical and modelling approach for biomimetic meniscal replacements
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-06-11 → 2020-06-10
- Финансиране от ЕС
- 176 123 €
- Участници
- 2
- Схема
- MSCA-IF-EF-ST
Линиите свързват координатора с партньорите.
Накратко на български
Биомеханиката на коленния менискус се анализира чрез микроскопия и тестове за устойчивост на тъканта. Това помага при създаването на по-добри изкуствени замени, които да имитират естествената функция на ставата.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Biomechanics of menisci: a multiscale experimental, theoretical and modelling approach for biomimetic meniscal replacements
The project focuses on the biomechanics of the knee meniscus and understanding the structure-function relationship of this tissue. This research has touched upon a number of length scales from nano-macro and on a number of research fields from advanced microscopy and imaging to experimental mechanical testing, involving new mathematical models used for large scale simulations of the knee joint. The scientific objectives: • Meniscal internal architecture: Advanced microscopy and imaging techniques elucidate the internal structure of the meniscus and how it change in the different regions of the meniscus. Micro-structural quantities such as: porosity, fractal dimension, pore size, tortuosity of channels were successfully quantied. This is the only to-date detailed study on the knee meniscus. • Mechanical characterization: Mechanical and poromechanics testings allow to study the behavior of the tissue under a set of quasi static and dynamic loading. Spatial dependent Hyperelastic, viscoleastic and poroelastic parameters are identified. More than 150 tests are planned/conducted. • Material models: A number of material models are explored, including an innovative fractional poroelastic combined with large deformations. The focus is s to try to understand which is the simplest material model that can be used to reproduce the behavior of the tissue. The output is to extrapolate material parameters needed to run a patient specific Finite Element Model (FEM) of the human knee. • Patient Specific model of the knee: A detailed FEM of a human knee is been built and used as a benchmark problem in order to understand what is the role of the meniscus on the contact pressure and contact areas in the femoral and tibial cartilage. It has been noted that contact is a great issue when changing material model of the meniscus. Also it was highlighted that anisotropy makes the difference when comparing linear/non linear (time dependent and non time dependent).
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
The meniscus plays a critical role in load transmission, stability and energy dissipation in the knee joint. Loss of the meniscus leads to joint degeneration and osteoarthritis. In a number of cases replacement of the resected meniscal tissue by a synthetic implant might avoid the articular cartilage degeneration. None of the available implants presents optimal biomechanics characteristic due to the fact the biomechanics functionality of the meniscus is not yet fully understood. Mimicking the native biomechanical characteristics of the menisci seems to be the key factor in meniscus replacement functioning. This is extremely challenging due to its complex inhomogeneous microstructure, the lack of a full experimental characterization of the material properties and the lack of 3D theoretical, numerical and computational models which can reproduce and validate the experimental results. Therefore, the aim of this work is a thorough understanding of the menisci biomechanics with the view of translating the knowlege to the orthopeadic implants arena. The objective of the proposal be achieved through (i) designing and performing a range of innovative experimental tests to characterize the behaviour of the meniscus tissue at the micro and macroscale, (ii) building an appropriate and novel multiscale anisotropic model at the tissue level which takes into account the fractal dimension of the porous menisci’s tissue, (iii) implementing the material model in commercial finite element (FE) software and (vi) build and validate an accurate FE biomechanical model of the knee joint (which includes the meniscus) in order to model the biomechanical behaviour of the menisci when subjected to a range of mechanical stress which is not reproducible in an experimental context.
Оригинален текст от CORDIS (на английски).
Участници
- UNIVERSITE DU LUXEMBOURG · ESCH-SUR-ALZETTEКоординаторЛюксембург
- UNIVERSITA DEGLI STUDI DI PALERMO · PalermoИталия
Връзки
Данни: CORDIS, © Европейски съюз