H2020Индивидуална стипендия2018–2020

COHEMEX · Molecular mechanisms controlling exit from mitosis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-09-01 → 2020-08-31
Финансиране от ЕС: 157 846 €
Участници: 1
Схема: MSCA-IF-EF-ST

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Накратко на български

Молекулярните механизми, които контролират края на клетъчното делене, се изучават чрез дрождите Saccharomyces cerevisiae. Разбирането на тези процеси помага за изясняване на причините за генетичната нестабилност и развитието на рака.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Molecular mechanisms controlling exit from mitosis

This Marie Skłodowska Curie Action (MSCA) entitled “Molecular Mechanisms Controlling Mitotic Exit” aimed at revealing novel mechanisms that control exit from mitosis using the eukaryotic model S. cerevisiae. Cancer, the uncontrolled division and spread of cells, represents one of the most important causes of death in Europe and all over the world. Understanding how cells control their division is the key to comprehend and cure cancer. Eukaryotic cells divide through mitosis to produce new cells with identical DNA. Yet, mitosis has to be ended for the two cells to be separated to become individual cells with the capacity to further divide. This occurs by a process called mitotic exit. Mitotic exit is a critical step during cell division. Failure to control mitotic exit is the key cause of aneuploidy and genomic instability, which are hallmarks of cancer. Unravelling novel mechanisms of control, this MSCA has significant impact on understanding and treatment of cancer. Formal objectives of this MSCA is to understand the molecular mechanisms by which a novel potential mitotic exit influencer impinges upon mitotic exit in the model eukaryote Saccharomyces cerevisiae (a) by establishing how it effects mitotic exit parameters (b) by identifying its downstream effectors in mitotic exit control (c) by determining its cell cycle dependent interaction partners. In addition, this MSCA aims development of the researcher as an independent accomplished researcher.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Cancer, the uncontrolled division and spread of cells, represents one of the most important causes of death in Europe and all over the world. Understanding how cells control their division is the key to comprehend and cure cancer. Eukaryotic cells divide through mitosis to produce new cells with identical DNA. Yet, mitosis has to be ended for the two cells to be separated to become individual cells with the capacity to further divide. This occurs by a process called mitotic exit. Mitotic exit is a critical step during cell division. Failure to control mitotic exit is the key cause of aneuploidy and genomic instability, which are hallmarks of cancer. Therefore, gaining a comprehensive knowledge of mitotic exit regulation will have significant impact on understanding and treatment of cancer. In this project, the researcher will uncover a novel mechanism that control exit from mitosis mitotic. This novel regulation has the potential to define a molecular target to fight cancer in long term. Researchers previous research experience puts her in a unique position to perform this project. This fellowship will also allow the researcher to build a successful academic career, to acquire new expertise and soft skills, and to establish future collaborations through dissemination, communication and training. Furthermore with this fellowship, researcher will help increase public awareness of science through outreach activities.

Оригинален текст от CORDIS (на английски).

Участници

KOC UNIVERSITY · IstanbulКоординаторТурция