H2020Индивидуална стипендия2018–2020

GutMIND · Gut microbiota-Microglia Interactions in NeuroDevelopment

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-06-01 → 2020-05-31
Финансиране от ЕС: 175 866 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между чревните бактерии и мозъка се проучва чрез влиянието на антибиотиците върху поведението и нервната система на мишки в ранен етап от развитието им. Това помага да се разбере как промените в микробиома влияят върху детските психични разстройства.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Gut microbiota-Microglia Interactions in NeuroDevelopment

Childhood psychiatric disorders are alarmingly common, but there remain many unknowns about how they start, what factors can contribute to their onset or maintenance, and the best ways to treat them. There is a long history of research showing that certain points of early life (known as “critical windows”) are particularly important for normal development of the brain and behaviour. However, not all the contributing factors are well-defined. The GutMIND project asked whether interactions between the brain and the body, and especially the bugs living in our guts (the “gut microbiome”), have critical windows. We tested whether microbiome disruption by antibiotics during early life has implications for neural and behavioural outcomes in mice. This is particularly important to understand given the high rates of antibiotic use in modern society; antibiotics not only kill harmful bacteria but also deplete the microbiome, with little known about the collateral impact on our brains and behaviour, especially in developing individuals. Our results addressing these questions will be published soon.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Childhood psychiatric disorders are alarmingly common, yet current gold-standard treatments fall short in creating lasting, meaningful improvements for many individuals. To improve outcomes, it is imperative to enhance our understanding of pathways to disordered development. Recent advances in the study of microglia-neuron interactions and critical period signals suggest that disruption in the developmental timing of these neural events may contribute to early-onset psychopathology. However, the factors that modulate these signals have not been well-defined. The GutMIND project will test the hypothesis that complementary maturation of the microbiota and the brain during critical windows of development may be one contributing factor. For the first time, the (sex-specific) trajectory of the microbiota’s influence on behavioural and neural outcomes during early host development will be characterised in detail. This will generate testable hypotheses regarding potential mechanisms and thus potential treatments to ameliorate the effects of microbiota depletion during critical periods. Specifically, this will be achieved by experimentally testing 1) metabolite pathways that may contribute to the microbiota’s influence on microglia-neuron communication and 2) the mediating role of the microglia in microbial influences on behaviour. In line with the objectives of the MSCA fellowships, the research project has been designed to facilitate the applicant’s career development by providing advanced training in supportive host environments that will diversify her research competencies, foster her managerial and teaching skills, and strengthen her research profile and professional network. In the process, public, industry, and scientific audiences will be engaged in the outcomes of the action through a multi-pronged communication, dissemination, & exploitation strategy that will promote positive mental health development in the EU and beyond.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK · CorkКоординаторИрландия