H2020Индивидуална стипендия2018–2020

SKIN SUBSTITUTE · Development of hybrid artificial skin substitute for chronic diabetic wounds

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-08-01 → 2020-08-31
Финансиране от ЕС: 187 866 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Хибридна изкуствена кожа се разработва за лечение на хронични рани при диабетици, като например язвите по стъпалата. Тя помага за регенерацията на тъканите, за да се намали рискът от инфекции и ампутации на краката.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Development of hybrid artificial skin substitute for chronic diabetic wounds

In recent years, diabetes has become a global disease with accelerating incidence in newly industrialized countries whose societies have become increasingly westernized. In Ireland, 1 in 10 people is currently diagnosed as having diabetes, which is a disease that occurs when the sugar (glucose) level in the blood is too high. A common side effect of poorly controlled diabetes is damage to nerves and blood vessels in the legs and feet, which can result in the breakdown of skin, and the development of non-healing open wounds called diabetic foot ulcers. The annual cost of treating patients with this condition in Ireland is estimated at around €1 billion. Typical therapies for diabetic foot ulcers are daily wound dressing and application of ointments or antibiotics. However, most of the time these treatments do not completely cure the problem of slow wound healing that is associated with diabetic foot ulcers, and in many cases, these wounds can become infected and it is necessary to amputate the lower leg. In Europe, it is estimated that the number of adults diagnosed as diabetic will increase to 43 million by 2030. Around 15% of diabetes-affected patients develop a diabetic foot ulcer, and of these patients, approximately 20% will require amputation of the lower leg. This project aims to develop multicomponent-based artificial skin. The use of an artificial skin substitute (referred to as an artificial extracellular matrix scaffold (aECM) for diabetic wound healing would be of great help in the treatment of diabetic foot ulcers, promoting healing of the wound by providing all of the necessary components for the skin to regenerate. The overall research aim of the project was to develop for the first time a 3-dimensional aECM scaffold incorporating chemically engineered chondroitin sulfate (CS) and anti-inflammatory cytokine to resolve the cytokine imbalance in the chronic diabetic wound (Figure 1). The native ECM mimicking scaffold will act as a customized platform for technologies that deliver anti-inflammatory cytokine and chemically engineered CS to resolve the multi-faceted nature of the pathology of chronic diabetic wounds. The proposed aECM scaffold combined with anti-inflammatory cytokine and chemically engineered CS is designed based on the limitation of marketed skin grafts. The hypothesis underlying the project is that an aECM scaffold incorporating anti-inflammatory cytokine and chemically engineered CS will reduce the chronic inflammation and promote angiogenesis and re-epithelization in a diabetic mice ulcer model.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

It is estimated that the incidence of diabetes in Europe will affect 43 million people by 2030. 15% of diabetic patients develop a diabetic foot ulcer (DFU) with 14-24% of these patients requiring amputation. Mortality following amputation of 50–68% is comparable or worse than for most malignancies. My strategy will develop for the first time a skin substitute which combines a biopolymer and a functionalized synthetic FDA approved polymer incorporating bioactive components and AgO and ZnO nanoparticles as antibacterial agents. The cellular compatibility of the hybrid skin substitute will be assessed on fibroblast, keratinocyte and hMSC in a 3D cell culture model. The antimicrobial efficacy will be assessed in vitro and in vivo. The optimised scaffold will be assessed in an alloxan-induced diabetic rabbit ulcer model with gold standards Integra® and Alloderm® skin grafts acting as commercial controls to validate the commercial potential of the technology. Progress to completion will be reviewed by a Research and Professional Development Plan which will provide both discipline-specific and complementary technical training (molecular biology, diabetic wound healing in vivo models, and histological and stereological techniques) and generic and complementary transferable skills training (e.g. intellectual property, leadership skills, motivation skills, communication skills, leveraging non-exchequer funding, regulatory affairs, clinical trial design, reimbursement strategies, medical device evaluation and regulatory affairs). I will benefit from Prof Pandit’s and Prof Dulce Papy-Garcia (secondment) international collaborative network in the field of diabetic wound healing. This training will facilitate me to achieve my future career goals of achieving a position of professional maturity, diversity and independence by establishing my own research group at a leading European institution and enabling me to translate innovative therapeutic interventions to the clinic setting.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF GALWAY · GalwayКоординаторИрландия