H2020Индивидуална стипендия2019–2021

SYMMUNITY · SYMbiosis, Microbiota and immUNITY

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-04-01 → 2021-11-24
Финансиране от ЕС: 212 195 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Микробиотите при мравките се анализират, за да се разбере дали бактериите се развиват заедно с видовете или се адаптират към тяхната среда. Това помага да се разберат механизмите на имунната защита и начина, по който организмите си сътрудничат за оцеляване.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

SYMbiosis, Microbiota and immUNITY

Symbiosis and sociality define the evolutionary success of life, but the large-scale synergy between hosts and microbiotas is poorly understood. The present project aims to develop a set of phylosymbiotic approaches to begin to understand how and why hosts have evolved in association with microbiota that shape host ecologies. In principal, microbiota can either evolve phylogenetically with the host diversification or evolve convergently with the host ecological adaptations. Social insects are interesting targets for phylosymbiotic analysis because microbiomes combine functions of nutrient supplementation, individual immunity and colony-level immunity. This applies most explicitly to the ants, which have huge species diversity (>14,000 species), massive ecological footprints (dominant in biomass in most terrestrial ecosystems), and high diversity in life styles (e.g. predatory, omnivory, herbivory). The overall goal of the project is to assemble and analyze metagenomic data for at least 50 ant species to understand 1) The evolutionary and functional dynamics of homologous or analogous microbiota across the family Formicidae (ants), and 2) the functional adaptations that have shaped immune defenses across the ant subfamilies and genera. I have successfully characterized microbiomes from 60 ant species (50 different genera across 10 out of 12 total existing subfamilies) using 16S amplicon sequencing. The majority of microbiotas does not evolve phylogenetically with the their host diversification. There are two clades of ant species, representing four different genera (Camponotus, Polyrhachis, Myrmecina, Acanthomyrmex), that show significant signs of phylosymbiosis. Preliminary results further suggest that the host symbiotic bacteria belonging to Enterobacteriaceae is likely to be the candidate partners of these phylosymbiotic relationships. Additionally, there is an overall trend that diet specialization correlates with microbiota diversity, albeit insignificant with the present data. In general, the predatory strategies appear to maintain richer microbiota diversity than other diet strategies.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Symbiosis and sociality define the evolutionary success of life, but the large-scale synergy between hosts and microbiotas is poorly understood. New phylosymbiotic approaches aim to understand how and why hosts have evolved in association with microbiota that track and shape host ecologies. At present it is virtually unknown whether and where clear phylosymbiotic signatures of coevolution exist. In principle, microbiota can either track the phylogenetic diversification or the biogeography of hosts. The former would imply that phylosymbiotic trees are largely homologous, while the latter would induce convergent evolution and be more informative about habitat-specific adaptations. Social insects are interesting targets for phylosymbiotic analysis because microbiomes combine functions of nutrient supplementation, individual immunity and colony-level immunity. This applies most explicitly to the ants, which have huge species diversity (>14,000 species), massive ecological footprints (dominant in biomass in most terrestrial ecosystems), and high diversity in life styles (e.g. predatory, omnivory, herbivory, aphid husbandry, fungus farming). The ants also have a unique variety of glands to produce antibacterial compounds that may interact with microbiota, and some lineages have domesticated antibiotics-producing bacteria. I propose to assemble and analyze metagenomic data for 50 ant species (covering 15 subfamilies) exploiting a grand sampling initiative by the Global Ant Genomics Alliance (GAGA, antgenomics.dk) to understand: 1) The evolutionary and functional dynamics of homologous or analogous microbiota across the family Formicidae (ants), and 2) the functional adaptations that have shaped immune defenses across the ant subfamilies and genera.

Оригинален текст от CORDIS (на английски).

Участници

KOBENHAVNS UNIVERSITET · KOBENHAVNКоординаторДания