DECISIONSEQ · Neural bases of behavioral choices and sequences
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-11-26 → 2020-12-07
- Финансиране от ЕС
- 173 076 €
- Участници
- 1
- Схема
- MSCA-IF-EF-RI
Линиите свързват координатора с партньорите.
Накратко на български
Невронните механизми, които контролират избора между взаимно изключващи се поведения, се проучват чрез мозъка на ларви на дрозофила. Разбирането на тези процеси помага да се разберат нарушенията при различни невропсихиатрични разстройства.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Neural bases of behavioral choices and sequences
Many behaviors are physically mutually exclusive and therefore cannot occur simultaneously. Competitive interactions must exist that ensure that when one behavior is selected, other, competing behaviors are being suppressed. The outcome of these competitive interactions can be influenced by different factors and offen animals make different behavioral choices depending on the situation or their internal state. This allows the animal to do right thing given the circumstances, which is essential to ensure survival across species. Indeed the capacity to choose appropriate behaviours is impaired in many neuropsychiatric disorders. However, the neural circuit mechanisms that ensure this flexible selection of behaviors are not known with cellular and synaptic resolution. This is due to the difficulty in establishing causal relationships between single neurons and behaviors and mapping synaptic connectivity across the nervous system in big and complex brains with many neurons and many connections. To overcome these difficulties, we take advantage of Drosophila larva to address these questions. It has a compact brain which allowed the volume of electron microscopy (EM) images of the entire nervous system to be acquired and neuronal circuits can be mapped with synaptic resolution across the nervous system. In addition, the powerful genetic tools and rapid reproductive cycle make it possible to manipulate neuronal activity in a cell-type specific manner and quickly detect the resulting behavioral changes and thus establish the causal link between neurons and their behavior function. Drawing on the power of these methods which allowsto identify entry points into the circuits and then reconstruct their connections we investigated the neural basis of competitive interactions between behaviors that larvae perform in response to an external stimulus. This work set the basis for further investigations of the detailed neural circuits mechanisms of competitive interactions and their modulations by contextual and internal state information at the level of molecules, neural networks and behavior by the researcher at her next postion as a team leader and as preliminary work to secure funding for these investigations.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
It is essential for survival across the animal kingdom to make appropriate choices depending on the environmental context and the internal state. Nevertheless, how decision-making is implemented in the nervous system by specific circuits remains a significant gap in our knowledge. Many actions are physically mutually exclusive so competitive interactions must exist to enable the selection of one behavior and concomitant full suppression of all alternatives. Often, behaviors are not single actions but multiple actions organized into sequences that allow the animals to achieve their goals and mechanisms must be in place to regulate the transition between the behaviors in a sequence. Here again the network architecture underlying the generation of action sequences is not known with synaptic resolution. The difficulty in determining the detailed network architectures underlying decision-making and sequence generation is primarily due to the challenges in mapping connectivity between neurons with synaptic resolution and establishing causality between neurons and behaviors with cellular resolution with the model systems used. We propose to study circuit mechanisms of selection, repression and transitions between actions and fill the above described knowledge gap. Our multidisciplinary approach will combine neural manipulation during behavior, electron microscopy (EM) reconstruction of neuronal connectivity with synaptic resolution in the tractable model system, the Drosophila larva with modeling and quantitative behavioral analysis. We aim at determining with unprecedented resolution the network architectures and circuit mechanisms underlying competitive interactions and sequence transitions. Determining basic principles of behavioral choice and sequence implementation in the tractable genetic model system will lay the basis for future investigations in larger, more complex systems.
Оригинален текст от CORDIS (на английски).
Участници
- INSTITUT PASTEUR · ParisКоординаторФранция
Връзки
Данни: CORDIS, © Европейски съюз