H2020Индивидуална стипендия2018–2020

nanoTOM · Conversion of natural plant nanovesicles into nutraceutical delivery system

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-10-01 → 2020-10-31
Финансиране от ЕС: 168 277 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нановезикулите от домати се изследват като естествени контейнери за транспортиране на полезни вещества в организма. Тези структури помагат за по-добрата абсорбция на хранителни компоненти, които иначе трудно се усвояват от чревните клетки.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Conversion of natural plant nanovesicles into nutraceutical delivery system

Nano-scale encapsulation is an innovative strategy that is emerging for the bioavailability enhancement of poorly absorbed high-value bio-actives. In this context, the overall aim of nanoTOM is to exploits edible plant-derived nanovesicles as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. NanoTOM focuses on nanovesicles from tomato (Solarium lycopersicum), a high commercial and nutritional value agricultural product. Plants contain numerous types of membrane-surrounded nanometer sized vesicles that are morphologically similar to mammalian extracellular vesicles (EVs). EVs can transfer proteins, oligonucleotides, lipids and other metabolites to recipient cells, and have been shown to play important roles in cell-to-cell, interspecies and inter-kingdom communication. Edible plant-derived vesicles are efficiently up-taken by intestinal cells, non-toxic, naturally contains an array of bioactives, and thus represents a valid resource for nanovectors. NanoTOM project has realized the following specific research objectives: 1. set-up an integrated analytical pipeline for the isolation, purification, characterization, encapsulation, uptake and toxicological profiling of plant-derived nanovesicles; 2. determined the physicochemical characteristics and biocargo composition of tomato-fruit and root exudate-derived nanovesicles by using the integrated analytical pipeline; 3. evaluated the toxicity and the bioactivity and encapsulation properties of the vesicles. None of these objectives have been addressed before. The results achieved in nanoTOM expanded the current knowhow in the edible plant –derived nanovesicles research field. Moreover, the results obtained in nanoTOM shows encouraging perspective towards industrialization.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Novel encapsulation approaches to create alternative delivery options for nutraceuticals are emerging as a promising strategy to enhance the bioavailability of poorly absorbed active food ingredients. In this context, nanoTOM aims to exploit edible plant derived nanovesicles and use them as vehicles for the encapsulation, protection, release and bioavailability enhancement of selected nutraceuticals. Plant cells secret phospholipid membrane-surrounded vesicles morphologically similar to mammalian extracellular vesicles. Exploitation of plant nanovesicles is promising although hampered by i) their difficult isolation and ii) the lack of knowledge of their biogenesis, molecular architecture, uptake and biological effects. The experienced researcher is a chemist with strong academic and pharmaceutical background in the isolation and analysis of bioactive compounds from medicinal plants who team-up with the Institute of Biosciences and BioResources (IBBR) with considerable expertise in extracellular vesicle research to realize a uniquely interdisciplinary research program. The research proposed here will realize the following concrete objectives:1. Set-up an integrated analytical pipeline for the isolation, characterization, encapsulation, uptake and toxicological profiling of plant nanovesicles.2. Use the pipeline to exploit different Solanum lycopersicum (tomato) nanovesicle populations regarding secretion mechanism, heterogeneity, biocargo composition, nutraceutical and encapsulation properties.Neither of these objectives have been addressed before and both have high potential to expand the knowledge in the field and to drive the research activity towards industrialization. The research objectives are integrated with concerted training objectives in plant, cellular and molecular biology and omics, outreach program, dissemination events and considerable knowledge transfer in the isolation and use of herbal nutraceuticals from the researcher to the IBBR host group.

Оригинален текст от CORDIS (на английски).

Участници

CONSIGLIO NAZIONALE DELLE RICERCHE · RomaКоординаторИталия