H2020Индивидуална стипендия2018–2020

PPOM-PTT · New Peptide-Polyoxometalate Hybrids for Antimicrobial Photothermal Therapy

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-09-01 → 2020-08-31
Финансиране от ЕС: 195 455 €
Участници: 1
Схема: MSCA-IF-EF-ST

Линиите свързват координатора с партньорите.

Накратко на български

Нови хибридни наночастици от пептиди и полиоксометалати се тестват за унищожаване на микроби чрез светлинна и топлинна терапия. Това помага за справяне с антимикробната резистентност, при която бактериите стават устойчиви на традиционните антибиотици.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

New Peptide-Polyoxometalate Hybrids for Antimicrobial Photothermal Therapy

Antimicrobial resistance is a global challenge in the near future. From last century, antibiotics have built the line of defense for protecting humanity from infectious diseases. However, many kinds of deadly microbes with antimicrobial resistance are gradually becoming a large threat in our society nowadays. In contrast with antibiotics, photothermal therapy as a physical therapeutic modality will open up broad prospects for tackle antimicrobial resistance. However, only few effort has been devoted to this field. In this proposal, we present a 2-year project to establish a new orientation of POM-based antimicrobial photothermal therapy. This pioneering research aims to combine photothermal POMs with cell-penetrating AMPs to fabricate several kinds of photothermal POM ‘antibiotics’ for antimicrobial therapy. This creation is original and innovative that will provide a promising approach to address the challenge of antimicrobial resistance. By linking the photothermal L-POV, D-POM and K-POM with -PLs, we will construct a new series of PEP-POMs nanoparticles by covalent synthesis or noncovalent self-assembly. Moreover, we plan to investigate the possibility for the emergence of antimicrobial resistance induced by photothermal therapy, which is unprecedented as well. This proposed research is inherently inter/multidisciplinary involving many research frontiers of POM chemistry, antimicrobial peptides, self-assembly, antimicrobial and photothermal therapy. We do believe that this line of research will attract lots of interests from scientists in many different fields of chemistry and biology. It is anticipated that new collaborations and broad impacts can be arose in the European Union or even worldwide as this new orientation presented in the literatures and at international conferences.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Antimicrobial resistance is a global challenge which is threatening the life and health of people from every country and region. Basically, most of the chemical or biological interferences may cause resistance to some extent. Recently, photothermal therapy (PTT) is attracting increasing attentions in anticancer researches and bringing enormous impacts in our scientific community. Inspired by this progress, we plan to construct a new class of peptides-polyoxometalates (PPOMs) hybrids for antimicrobial photothermal therapy. We do believe that this project will create a new research orientation in the interdisciplinary boundary between POM chemistry, photothermal therapy and antimicrobial therapy.To this end, we propose a reasonable route divided into three steps: (i) developing a series of PPOMs by covalent or noncovalent linkage of three kinds of POMs and epsilon-poly-L-lysines with 10, 15, 20, 25, 30 repeating units; (ii) endowing PPOMs with photothermal capacities by chemical reduction and establishing a standard method for photothermal antimicrobial experiments based on PPOMs; (iii) evaluating their photothermal antimicrobial activity against non-resistant and ampicillin-resistant E. coli and exploring their potentials to tackle the antimicrobial resistance. This proposal is appropriate for both beneficiary and host. Ms. She has experience in POM synthesis, anticancer therapy and self-assembly, which will be vital in this research. Besides, the expertise in Cronin’s group involving POMs, peptides synthesis, antibacterial evaluation and material characterization will be crucial for this proposal. More importantly, this project will become one step further in the research direction of Cronin's group.To conclude, this project will exert a strong influence in the field of POM chemistry and antimicrobial research, and the bilateral success between host and beneficiary will be achieved.

Оригинален текст от CORDIS (на английски).

Участници

UNIVERSITY OF GLASGOW · GlasgowКоординаторОбединеното кралство