MECHPREDPRO · Cellular mechanisms of predictive processing and its effects on perception
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2018-08-01 → 2020-07-31
- Финансиране от ЕС
- 171 461 €
- Участници
- 1
- Схема
- MSCA-IF
Линиите свързват координатора с партньорите.
Накратко на български
Невронните механизми на илюзорното възприятие се изследват чрез анализ на пирамидалните клетки, които могат да ни накарат да „видим“ обекти, които реално липсват. Разбирането на структурата на тези клетки помага да се обясни как мозъкът съчетава сензорните данни с предварителните ни знания.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Cellular mechanisms of predictive processing and its effects on perception
Our brains consist of different types of neurons that together create our mental world. Layer 5 pyramidal (L5p) neurons are the key neurons of the cerebral cortex that integrate information across cortical layers and provide the main output of the cortex to other brain areas. In our project we tried to better understand the role of L5p in mental processes, in particular in perception. It is easy to assume that perception of the world accurately reflects reality. However, work in psychology and neuroscience has demonstrated that perception is always a mixture of prior knowledge and sensory data. Hence, sometimes we do not perceive “what is out there”, but rather what the prior knowledge dictates. In fascinating examples, expectations can create perception of objects that are actually not there in the real world. Such illusory perception is not only pathological, but can also happen in healthy humans, for example if we expect something to happen or the context suggests that some object should be there. Another example of illusory perception are dreams. In our project we studied the neural mechanisms of illusory perception. We also wanted to demonstrate how taking into account the biophysical complexities of L5p cells help us to understand perception, prediction and conscious experiences. It is often assumed that neurons can be captured by simply assuming one process that sums the input and provides the output. However, in our project we tried to show that L5p cells consist of two compartments that have distinctly different roles. Our mental processing depends on the integration of these two compartments.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
Predictive processing is a leading theory of brain function. However, despite several conjectures it is unknown how predictive processing is implemented at the neural level. We will try to understand the exact role of the computations of the layer 5 pyramidal (L5p) cells within the framework of predictive processing. The experimental paradigm and the computational model used here are designed to answer, whether L5p cells carry predictions, as the theory of predictive processing suggests, or are they responsible for some other computation. To this end we will a) adapt experimental paradigms used with humans to study probabilistic computations in the mouse model, b) measure the dendritic input and somatic output of L5p cells in mice, c) capture this activity with computational models and d) manipulate the apical dendritic input and somatic output of L5p through noradrenaline antagonists. The project allows us to understand the mechanisms underlying predictions and their effect on perception.
Оригинален текст от CORDIS (на английски).
Участници
- HUMBOLDT-UNIVERSITAET ZU BERLIN · BerlinКоординаторГермания
Връзки
Данни: CORDIS, © Европейски съюз