H2020Индивидуална стипендия2018–2020

PORTAL · Personalized oncology for refractory and relapsed lymphoma using humanized patient derived othotopic xenografts (ImmunePDOX)

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2018-04-01 → 2020-03-31
Финансиране от ЕС: 170 122 €
Участници: 1
Схема: MSCA-IF-EF-RI

Линиите свързват координатора с партньорите.

Накратко на български

Лимфомите при хора се пренасят в имунно потиснати мишки, за да се създадат модели, които имитират реалния тумор. Това помага за разбирането на механизмите на лекарствената резистентност и избора на подходяща терапия за всеки пациент.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Personalized oncology for refractory and relapsed lymphoma using humanized patient derived othotopic xenografts (ImmunePDOX)

Lymphomas are a group of heterogenous blood cancers that arise from B or T lymphocytes and occur in 12 cases in 100,000 inhabitants each year. The most frequent B cell lymphomas are B-cell non-Hodgkin’s lymphomas (B-NHL). The 50% of B-NHL patients are refractory or relapse to the first line of treatment and 30% of them die with progressive disease. Some T cell lymphoma subtypes are also not curable and progress rapidly developing resistance to treatment. Therefore, therapeutic resistance represents a major treatment challenge for lymphoma patients. Select the best therapeutic options for each patient to overcome therapy resistance is an overriding priority. To do that it is necessary to improve our knowledge of the molecular mechanisms involved in therapy resistance and it is essential to dispose of good preclinical models for lymphoma that allow the combination of molecular and therapeutic studies. Patient derived orthotopic xenografts (PDOX) are the most advanced preclinical models in which human tumors are implanted in immunosuppressed mice at the same organ as the tumor is growing in the patient (orthotopic implantation) providing a similar tumor microenvironment. PDOX preserves the same histologic and genetic characteristics and similar pharmacological response pattern than its patient’s tumor precursor. PDOX can also be more humanized by engrafting human immune cells in the immunosuppressed mice. There is a lack of representative PDOX for lymphomas. In this project, we proposed to develop the technology to generate humanized PDOX for refractory and relapsed lymphomas to generate a proof-of-concept for their use in personalized oncology strategies in clinical practice. Our approach was to generate lymphoma PDOX by implanting patient’s tumors in lymphoid tissues and to humanize them using components of the immune system of the same patients from whom the models have been derived.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

This proposal is a “PORTAL” to re-incorporate Dr. Lourdes Farre from the Oswaldo Cruz Foundation (FIOCRUZ) in Brazil to Europe at the Catalan Institute of Oncology (ICO), a part of the Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain. She will be supervised by Dr. Alberto Villanueva, leader of the Resistance, Chemotherapy and Orthotopic Xenograft Models Group and Director Board of the EuroPDX (www.europdx.eu) in collaboration with Dr. Ana Sureda, Head of the Hematology Department (ICO). Dr. Farre worked at FIOCRUZ for 12 years where she relevantly contributed in lymphoma research and acquired maturity as an independent researcher. Dr. Farre will contribute to ICO/IDIBELL initiating a new research line in resistance in hematological cancers and transfer her knowledge in HTLV-1 infection. She will also contribute to the ICO Hematology Service with a personalized oncology strategy for clinical oncology practice. Knowledge and preclinical models could be transfer to the IDIBELL`s spin-off Xenopat and Pharmaceuticals. She will have access to a solid multidisciplinary training program that will provide qualitative improvement on her career and a privileged position to be reintegrated in a long term research position in Europe. She has always combined scientific activity with educational interventions. Besides scientific dissemination, she programmed public engagement activities. This proposal is a proof-of-concept of personalized oncology for refractory/relapsed lymphoma and aims to study the mechanisms involved in response to therapy using preclinical humanized orthotopic models. Relapsed/refractory lymphomas represent a major treatment challenge and general treatment paradigm has remained empiric. Defining the best therapeutic option for each patient and overcoming such resistance is a priority. Humanized and orthotopic approach is original and innovative. PORTAL reflects the policy priorities of the Europe 2020 strategy and considers gender issues.

Оригинален текст от CORDIS (на английски).

Участници

FUNDACIO INSTITUT D'INVESTIGACIO BIOMEDICA DE BELLVITGE · L'Hospitalet De LlobregatКоординаторИспания