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H2020Докторантска мрежа2019–2023

IMPROVE-PD · Identification and Management of Patients at Risk – Outcome and Vascular Events in Peritoneal Dialysis

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-01-01 → 2023-06-30
Финансиране от ЕС
3 970 006 €
Участници
22
Схема
MSCA-ITN

Линиите свързват координатора с партньорите. За проекти отпреди 2014 г. CORDIS не винаги дава точни координати. Тези точки са на ниво град или държава.

Накратко на български

Молекулярните механизми на възпалението при пациенти на перитонеална диализа се анализират, за да се идентифицират тези с повишен риск от сърдечно-съдови заболявания. Това помага за създаването на индивидуално подходящо лечение, което да намали усложненията и смъртността при тези пациенти.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Identification and Management of Patients at Risk – Outcome and Vascular Events inPeritoneal Dialysis

Chronic kidney disease (CKD) afflicts 8% of the European population and increase risks of infections, cardiovascular disease (CVD) and death. It might progress to end-stage renal disease, prevalent in 250,000 people in Europe, from infants to geriatrics, that depend on a life-saving renal replacement therapy such as peritoneal dialysis (PD). During PD, a fluid is instilled into the peritoneal cavity so ultrafiltration (UF) and diffusion occur across the peritoneal membrane (PM) to eliminate waste materials and water from the body. Although PD offers economic and performance benefits over haemodialysis (HD), both therapies accelerate atherosclerosis and CVD. Improved understanding of the molecular mechanisms involved in inflammation, and their connection with CVD will help in the design of interventions to reduce PD-related complications. Inter-sectoral research and well-trained researchers with amultidisciplinary skills are crucial to drive improvements in PD therapy. A risk-adjusted individualized PD approach is also crucial. IMPROVE-PD consortium was born to allow close collaboration between industrial and academic sectors, working in partnership with patients and public to achieve these ambitious targets. IMPROVE-PD aimed to reduce CVD and mortality in PD patients by enabling tailored approaches targeted to the individual characteristics of the patient. To achieve this, the consortium worked on 3 different scientific work packages (WP), aiming at: 1. “Identifying the patient at risk who will benefit from individualizing therapy” 2. “Understanding the patient at risk” 3. “Early phase studies of novel anti-inflammatory therapies in PD” Throughout these years, the consortium has impacted on the social, economic and scientific areas, strongly contributing with a large amount of new knowledge to improve patients’ quality of life. It combined PD registries and biobanks, and innovative experimental models to delineate the role of local and systemic, metabolic and immune system-mediated responses on patient outcome. Based on predictive algorithms and pathophysiological markers signatures, therapeutic actions resulted in improvement and personalisation of PD therapy.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Peritoneal dialysis (PD) is an underused life saving renal replacement therapy for end-stage kidney disease. Nevertheless, PD patients remain at high risk for poor outcome, most notably excessive risk of cardiovascular disease. There is an unmet need for a risk-adjusted individualized PD approach. The IMPROVE-PD consortium provides 15 Early Stage Researchers (ESRs) in 11 partner institutes located in 7 different countries a state-of-the-art, multidisciplinary and intersectoral pan- European training programme including input from academic, clinical and industrial stakeholders. Network-wide and local training activities, individual research projects, intersectoral secondments and short laboratory visits will provide key generic skills and will prepare ESRs for future roles as highly skilled researchers in Europe. Well-phenotyped patient cohorts, and novel experimental models and techniques will be exploited by the ESRs, mentored by an excellent supervisory team, to improve future management of the PD patient at risk. This joint effort encourages productive collaboration between industrial and academic sectors though integrated projects and shared goals. Key findings will be communicated to a broad range of stakeholders through state of the art methods. IMPROVE-PD will give rise to a new generation of experts in PD with outstanding interdisciplinary research skills, intersectoral understanding and with perspective to pursue their careers in this scientific and industrial field. It will enable timely identification of the PD patient at high risk for adverse outcome, develop understanding of underlying pathomechanisms, and within an iterative process between research groups foster the development of innovative approaches to individualized treatment by targeting revealed pathomechanisms. Through these approaches, the ITN will achieve refinement of PD fluids, PD therapy and cardiovascular risk reduction.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз