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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2019–2023

aDDRess · Joint Training and Research Program on Chromatin Dynamics and the DNA Damage Response

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-03-01 → 2023-12-31
Финансиране от ЕС
4 011 939 €
Участници
18
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Динамиката на хроматина и механизмите за поправка на увредената ДНК се изучават чрез различни генетични модели. Това помага за разбирането на процесите по поддръжка на генома при развитието на организма и при различни заболявания.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Joint Training and Research Program on Chromatin Dynamics and the DNA Damage Response

The Program "Joint training and research program on chromatin dynamics and the DNA damage response” (aDDRess - ITN) is an H2020-funded Marie Curie Initial Training Network (ITN) that is coordinated by the Institute of Molecular Biology and Biotechnology (IMBB), at the Foundation for Research and Technology-Hellas (FORTH) , Heraklion , Crete , Greece (Coordinator: Prof. George A. Garinis). The overall objectives of the aDDRess-ITN are to i. establish a European research platform of excellence in the field of chromatin dynamics and the DDR by integrating research from basic mechanisms to translational research applications, ii. create a Network dedicated for the training of ESRs promoting their independent careers, their own scientific goals and future employment prospects and to transform our current successful, long-term collaborations into a stronger intellectual and training network while building durable links between the participating labs and the industry (SMEs). The aDDRess ITN focuses on a series of relatively short-term objectives that are achievable within the time course of the Network project. These objectives are centered to 15 ESRs and are grouped into three into three functionally-linked thematic areas i.e. 1. DNA Repair mechanisms & chromatin architecture (WP4), 2. Genome maintenance in development and disease (WP5) and 3. Novel approaches to study DNA repair-deficient disorders (WP6). In addressing these aims, we have put forward a multidisciplinary approach to study this central thematic area at the molecular, cellular and systems level by assembling a group of scientists and industrial partners with cross disciplinary expertise and capabilities. The Program includes several genetic model systems employing cutting-edge technologies and tools, some of which have been specifically developed by the participants of this network. The consortium combines top-level, state-of-the-art interdisciplinary research skills ranging from basic molecular mechanisms and ‘omics’ level understanding to translational research and clinical applications.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

Defects in DNA repair trigger a number of devastating health complications ranging from developmental abnormalities to the premature onset of age-related diseases, including the metabolic syndrome, neurodegeneration and cancer. To counteract genome instability, cells have evolved a battery of DNA repair mechanisms ensuring that their genome remains functionally intact and is faithfully transmitted to progeny. Recent work reveals that DNA repair factors play additional roles in vital biological processes, including nucleosome remodeling, chromatin architecture, RNA biogenesis or the transcription activation of genes involved in cellular reprogramming and growth. These recent discoveries have pushed the DNA repair field forward and towards new grounds requiring a series of sophisticated functional and multidisciplinary approaches. Based on these novel scientific paths, we have carefully designed the “aDDRess” consortium on the basis of past excellence of the individual participants and their relevance to the proposed field. The action addresses a major research topic i.e. DNA damage in development and disease with great socioeconomic impact in Europe and direct relevance to human health. The objectives of the program are: i. to create a European research platform of excellence in the field of DNA repair by integrating research from basic mechanisms to translational research applications, ii. to establish a Network dedicated to the high-quality training of ESRs promoting their independent careers and future employment prospects, iii. to transform our current successful, long-term collaborations into a stronger intellectual network and build durable links between the participating labs and the industry (SMEs). Understanding the relevance of genome maintenance pathways to human health will shed light onto the causal mechanisms of rare and widespread life-threatening diseases, including cancer.

Оригинален текст от CORDIS (на английски).

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Данни: CORDIS, © Европейски съюз