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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Докторантска мрежа2019–2023

TICARDIO · Thrombo-inflammation in cardiovascular disease

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-04-01 → 2023-11-30
Финансиране от ЕС
3 659 126 €
Участници
10
Схема
MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Взаимодействието между възпалението на стените на кръвоносните съдове и съсирването на кръвта при заболявания като инфаркт и инсулт е в центъра на анализа. Разбирането на тези процеси помага за разработването на по-ефективни клинични стратегии за пациентите с висок риск.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Thrombo-inflammation in cardiovascular disease

Despite medical advances, age remains the major risk for cardiovascular diseases with arteries being at risk of inflammation and thrombosis. To date most pathological processes of CVD including myocardial infarction, stroke, inflammation and thrombosis have been investigated well. However, the interplay of these processes are often neglected. This project is looking at the interactions between the inflammation of the vessel walls and the coagulation of blood and how interactions of these events lead to CVD processes – namely Thrombo-Inflammation in CARDIOvascular disease (TICARDIO). TICARDIO is bringing together experts in basic, clinical and industry research thus providing not only a unique training environment for young researchers, but also the expertise to unravel unknown interactions leading to CVD. Understanding these interactions will contribute to concepts of viable clinical strategies beneficial for patients at risk of suffering from stroke, myocardial infarction, or venous thromboembolism.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The demographic change with aging populations places a heavy burden on health care systems worldwide. Despite all medical advances, age remains the major risk for cardiovascular disease (CVD), one of the top two killers. The aging vasculature provides an environment in which the finely tuned interplay between diverse cell types becomes disarrayed and thus fosters both, inflammation and thrombosis. For atherosclerosis and major vascular complications, i.e. myocardial infarction and stroke, inflammation and thrombosis are central pathological processes that have commonly been investigated independently, but now need integration within the new concept of 'vascular thrombo-inflammation'. Four beneficiaries have formed a strategic alliance to unravel the multifaceted mechanisms involved in thrombo-inflammation in the setting of CVD and identified interconnected research projects that benefit from the collaboration between outstanding centres in France, Germany and The Netherlands. Using unique and complementary advanced technologies, TICARDIO will dissect the mechanistic linkages between inflammation and thrombosis, investigate the multicellular interactions in the vasculature as drivers for thrombo-inflammation, and translate new concepts by multi-omics approaches into patient populations. The programme will train the next generation of basic and translational researchers by exposing them to a multidisciplinary research environment at major academic centres and a range of entrepreneurial and business settings at small and large pharmaceutical companies in Europe. The completion of an independent project in a research area with high unmet medical need will foster the development of creative, open minded and broadly knowledgeable biomedical researchers who are competitive for successful academic and company careers all over Europe. TICARDIO’s structures and interactions will serve as a blueprint for future training programmes in emerging fields of cardiovascular medicine.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз