H2020Докторантска мрежа2019–2023

APPFlow · Active Pharmaceutical Production in Flow

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период: 2019-01-01 → 2023-06-30
Финансиране от ЕС: 909 518 €
Участници: 3
Схема: MSCA-ITN

Линиите свързват координатора с партньорите.

Накратко на български

Поточната химия заменя традиционното производство на лекарства на части с непрекъснати процеси, което позволява безопасното използване на запалими газове и силно реактивни вещества. Това помага за създаването на по-екологични методи за производство с по-малко отпадъци и по-нисък разход на енергия.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Active Pharmaceutical Production in Flow

APPFlow (Active Pharmaceutical Production in Flow) trained three Early Stage Researchers (ESRs) in innovative research centred on flow chemistry, an area that is essential for the pharmaceutical and fine chemical industries in Europe. APPFlow is a European Industrial Doctorate (EID) scheme and the three ESRs have worked towards obtaining a PhD (awarded by Queen’s University, Belfast) while collaborating closely with industrial collaborators (Arran Chemical Company and the Almac Group). The production of active pharmaceutical ingredients (APIs) and many other fine chemicals still relies on batch operations. Many modern efficient synthetic routes require hazardous reagents and conditions, which are dangerous to scale using batch reactions, for example, reactions that use highly reactive intermediates or flammable gases. Continuous operation allows much smaller reactors to be used, which makes the hazards associated with using dangerous conditions much easier to manage and therefore utilise on an industrial scale. APPFlow aims to develop safer and more efficient processes for the production of important chemicals. This is positive for society, as it means that these important chemicals are produced in a more sustainable manner, producing less waste, and requiring less energy. The programme has delivered the following: • industry relevant training that resulted in three ESRs with skills and knowledge in cutting-edge sciecne, related to the production of fine chemicals and APIs • innovative multidisciplinary research projects, producing knowledge that will benefit the European community as a whole. • ESRs with research expertise and transferable skills that are highly attractive to employers in industry and academia

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

APPFlow will develop Early Stage Researchers (ESRs) in innovative research through a focussed training plan centred on flow chemistry, essential for the pharmaceutical and fine chemical industries in Europe. The training programme and research proposed in APPFlow tackles the problems associated with the production of advanced intermediates en-route to Active Pharmaceutical Ingredients (APIs) in the pharma-industry. The proposal is aligned with important European research goals outlined in Horizon 2020. Specifically, this research will address areas related to Resource Efficiency, Health, Environment and Nanotechnology. The end goals align with those of the SPIRE 2030 targets and aims, most closely aligned with the goal of ‘a reduction of up to 20% in non-renewable, primary raw material intensity compared to current levels by 2030.’ It comprises of three training sites located in Ireland (1) and the UK (2) and involves multidisciplinary collaboration between academic and industrial partners, each with complementary expertise across a range of disciplines. The programme will train 3 ESRs who will gain state-of-the-art, transferable knowledge in a number of valuable areas such as organic chemistry, catalytic chemistry, chemical engineering, process design and economics. APPFlow will establish long-term collaborations and develop structured research and training relevant to industry and academia and result in highly trained and employable ESRs. At the end of the APPFlow programme, the ESRs will possess a multidimensional perspective to research, enabling them to address problems with a holistic approach. The ESRs will also develop a range of transferable “soft” managerial skills that will widen their potential career opportunities and ability to contribute to a range of different sectors. For example, they will receive business and entrepreneurship mentoring, which will assist them in becoming future business leaders.

Оригинален текст от CORDIS (на английски).

Участници

THE QUEEN'S UNIVERSITY OF BELFAST · BELFASTКоординаторОбединеното кралство
ALMAC GROUP UK LIMITED · CraigavonОбединеното кралство
ARRAN CHEMICAL COMPANY LIMITED · AthloneИрландия