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КартаВръзкиТемиБългарияНощта (K-TRIO)Мария Склодовска-КюриЗа ученициЗа учителиМетодологияИзненадай ме
H2020Обмен на изследователи2019–2024

REFRACT · Repeat protein Function Refinement, Annotation and Classification of Topologies

„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“

Период
2019-01-01 → 2024-06-30
Финансиране от ЕС
2 226 400 €
Участници
16
Схема
MSCA-RISE

Линиите свързват координатора с партньорите.

Накратко на български

Протеините с повтарящи се структури, които съставляват почти трети от човешките протеини, се анализират чрез нови методи за класификация и разпознаване. Това помага за по-доброто разбиране на еволюцията на организмите и механизмите на някои човешки заболявания и инфекции.

Този кратък обзор е генериран от изкуствен интелект

Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.

Резултати накратко

Repeat protein Function Refinement, Annotation and Classification of Topologies

Tandem repeat proteins (TRPs) exhibit considerable diversity, ranging from simple homorepeats detectable by their lack of sequence complexity to cryptic repeats of up to 40 residues per unit and even entire domains. Typically, repeat protein sequences fold into a modular structure characterized by the repetition of identical structural units. These sequences are ubiquitous in genomes and are overrepresented in complex organisms—for instance, they are present in nearly a third of human proteins. Tandem repeat proteins have found their ideal functional niche in biological pathways that require rapid evolution, such as host-pathogen interactions, and have played a crucial role in the evolution of eukaryotes by compensating for their lower mutation rates. Moreover, numerous studies over the past decade have linked repeat proteins to human diseases and emerging infectious threats, underscoring the critical nature of their functions. The REFRACT consortium was established to address major challenges in the field of tandem repeat proteins, including benchmarking and enhancing existing methods for detecting repeat regions and deepening the understanding of their functional mechanisms and evolution. As an international effort, REFRACT aimed to expand knowledge on the mechanisms of tandem repeat protein function and evolution by establishing a common classification and best practices. The consortium achieved these objectives through several key initiatives: benchmarking existing methods and defining their use-cases; coordinating efforts to analyze the roles of repeat proteins in biological pathways and organism evolution; providing detailed descriptions of their mechanisms; and developing and characterizing a widely accepted classification of repeat proteins based on sequence and structure. Starting with state-of-the-art computational tools and databases available at the time, REFRACT leveraged the complementary expertise of institutions across Europe and Latin America to drive a new level of characterization for tandem repeat proteins.

Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз

Цел на проекта

The REFRACT proposal answers the RISE call, aiming at the promotion of an international and interdisciplinary collaboration on tandem repeat proteins (TRPs) through the sharing of knowledge and expertise between partners via staff exchanges. REFRACT is an international consortium aiming to extend our knowledge on the mechanism of TRP function and evolution, establishing a common classification and best practices. Starting from available state of the art computational tools and databases, which have been mostly developed by REFRACT participants, it aims drive a new level of TRP characterization leveraging the complementary expertise of 7 EU MS and 9 TC institutions in Latin America, with the latter providing useful complementary expertises. This aim will be achieved by the following steps:Benchmarking different existing methods and defining their use-cases;Coordinating the necessary next steps to analyze TRP roles in biological pathways and organism evolution; Providing a detailed description of their mechanism of function, related to their structural properties, that can be of great importance in TRP-related medical research and biotechnological applications;Building a unified and commonly accepted TRP classification from sequence and structure as well as characterizing the relationship between the two.The REFRACT implementation will take advantage of the different expertises, supporting them by a combination of research-centered, training and dissemination activities. The secondment program is designed so that all the participating institutions will be actively involved not only in the production of scientific outcomes, but also be empowered with the responsibility of planning, monitoring and discussing project advancement. The broadest possible dissemination of the results will be achieved through dedicated activities, the propagation of results into ELIXIR core data resources (InterPro, and consequently UniProt) as well as possible industrial exploitation.

Оригинален текст от CORDIS (на английски).

Участници

Връзки

Данни: CORDIS, © Европейски съюз