NeuroAPA · Neurodevelopmental outcome in offspring conceived by parents at advanced parental age
„Хоризонт 2020“ — Действия „Мария Склодовска-Кюри“
- Период
- 2019-04-01 → 2021-07-31
- Финансиране от ЕС
- 175 572 €
- Участници
- 1
- Схема
- MSCA-IF-EF-SE
Линиите свързват координатора с партньорите.
Накратко на български
Връзката между късното родителство и рискът от неврологични разстройства при децата, като например аутизъм или шизофрения, е в центъра на анализа. Това помага да се разберат механизмите и епигенетичните промени в сперматозоидите, които влияят върху развитието на детето.
Кратко обяснение, генерирано от езиков модел по текста на CORDIS. Оригиналът е по-долу.
Резултати накратко
Neurodevelopmental outcome in offspring conceived by parents at advanced parental age
Since 1970s, social and economic factors (i.e., expansion of higher education, lifestyle, and economic wellbeing) lead to postponement of parenthood above age of 35. It is now estimated that the rate of first childbearing at advanced maternal age has reached 30% and that at advanced paternal age over 45%, in most developed countries. Current data from epidemiological reports identified advanced parental age as risk factor for pregnancy complications and for the onset of neurological and/or psychiatric disorders (e.g., autism, schizophrenia) in the offspring. However, how and at what extent advanced parental age may contribute to a poorer neurological/psychiatric outcome is still poorly described. In this context, the general aim of NeuroAPA was to contribute to our understanding of the mechanism behind the increased incidence of neurodevelopmental disorders in offspring conceived by aged parents. The work carried out within the project showed an association between conception at advanced age and pregnancy complications (e.g., miscarriage, peri-natal mortality) and identified epigenetic changes in the spermatozoa as candidate mechanisms behind the observed side effect of conception at advanced paternal age.
Текст от CORDIS, на английски · Данни: CORDIS, © Европейски съюз
Цел на проекта
In current society, a growing number of individuals is affected by mental disorders, thus representing a burden with significant health, social and economic consequences. Notwithstanding, the ethiology of mental disorders is still not fully understood, there is a growing evidence that current trend to delay first childbirth above age of 35 is a factor of risk for the onset of mental disorders (i.e. autism, schizophrenia) in resulting offspring. This “new” reproductive trend, caused by social and economic factors, has already allowed the birth of millions of babies worldwide. In the last decade, epidemiological studies have suggested that children conceived at advanced maternal age are at higher risk of autism spectrum disorders as well as psychotic and/or bipolar disorder and those conceived at advanced paternal age at higher risk of autism and schizophrenia. However, data from population-based investigation are often controversial, due to several confounding factors (i.e. health, socio-economic status, lifestyle), and information from animal studies are still limited. In this context, the assessment of neurological and/or psychiatric health of offspring conceived at advanced parental age (APA) is urgently needed. Moreover, understanding the mechanism(s) behind increased risk of mental affliction (i.e. autism and/or schizophrenia) will contribute to the identification of novel marker for neurologic/psychiatric disorders with a significant impact on basic science, society and health care services.“NeuroAPA” aims to identify structural and functional abnormalities in adult brain which may contribute to the increased risk of psychiatric disorders (i.e. autism, schizophrenia) in offspring conceived by parents at advanced parental age.
Оригинален текст от CORDIS (на английски).
Участници
- PERCUROS BV · 's-Gravenhage (Den Haag)КоординаторНидерландия
Връзки
Данни: CORDIS, © Европейски съюз